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Literature DB >> 18651209

Signal transduction in transgenic mouse models of human breast cancer--implications for human breast cancer.

Abstract

The advent of genetically engineered mouse models (GEMs) of human breast cancer, have provided important insight into molecular basis or human breast cancer. This review will focus on two of the most extensively studied mouse models for human breast cancer involving mammary gland specific expression of the polyoma middle T (PyV MT) antigen and of the ErbB2. In addition, this review will discuss past and recent advances in understanding relative contribution of the signaling pathways in tumor induction and metastasis by these potent mammary oncogenes.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18651209 DOI： 10.1007/s10911-008-9087-3

Source DB: PubMed Journal: J Mammary Gland Biol Neoplasia ISSN： 1083-3021 Impact factor: 2.673

123 in total

Review 1. Duality of p27Kip1 function in tumorigenesis.

Authors: Peter Sicinski; Sima Zacharek; Carla Kim
Journal: Genes Dev Date: 2007-07-15 Impact factor: 11.361

2. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.

Authors: Ioanna G Maroulakou; William Oemler; Stephen P Naber; Philip N Tsichlis
Journal: Cancer Res Date: 2007-01-01 Impact factor: 12.701

Review 3. The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter.

Authors: M D Sternlicht; M J Bissell; Z Werb
Journal: Oncogene Date: 2000-02-21 Impact factor: 9.867

4. Involvement of insulin receptor substrate 2 in mammary tumor metastasis.

Authors: Julie A Nagle; Zhefu Ma; Maura A Byrne; Morris F White; Leslie M Shaw
Journal: Mol Cell Biol Date: 2004-11 Impact factor: 4.272

5. Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis.

Authors: Nathalie Dourdin; Babette Schade; Robert Lesurf; Michael Hallett; Robert J Munn; Robert D Cardiff; William J Muller
Journal: Cancer Res Date: 2008-04-01 Impact factor: 12.701

6. ShcA signalling is essential for tumour progression in mouse models of human breast cancer.

Authors: Josie Ursini-Siegel; W Rod Hardy; Dongmei Zuo; Sonya H L Lam; Virginie Sanguin-Gendreau; Robert D Cardiff; Tony Pawson; William J Muller
Journal: EMBO J Date: 2008-02-14 Impact factor: 11.598

Review 7. Cyclin D1, EMS1 and 11q13 amplification in breast cancer.

Authors: Christopher J Ormandy; Elizabeth A Musgrove; Rina Hui; Roger J Daly; Robert L Sutherland
Journal: Breast Cancer Res Treat Date: 2003-04 Impact factor: 4.872

8. Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

Authors: S M Gorsch; V A Memoli; T A Stukel; L I Gold; B A Arrick
Journal: Cancer Res Date: 1992-12-15 Impact factor: 12.701

9. Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion.

Authors: John N Hutchinson; Jing Jin; Robert D Cardiff; Jim R Woodgett; William J Muller
Journal: Cancer Res Date: 2004-05-01 Impact factor: 12.701

10. Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice.

Authors: Masaharu Yamazaki; Takemi Akahane; Todd Buck; Hitoshi Yoshiji; Daniel E Gomez; Daniel J Schoeffner; Eijiro Okajima; Steven R Harris; Opal R Bunce; Snorri S Thorgeirsson; Unnur P Thorgeirsson
Journal: Carcinogenesis Date: 2004-05-27 Impact factor: 4.944

24 in total

1. The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.

Authors: Maryse Dagenais; Jeremy Dupaul-Chicoine; Todd Douglas; Claudia Champagne; Alexandre Morizot; Maya Saleh
Journal: Oncoimmunology Date: 2017-02-06 Impact factor: 8.110

2. BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer.

Authors: Philip H Jones; Wadie D Mahauad-Fernandez; Marisa N Madison; Chioma M Okeoma
Journal: Virology Date: 2013-06-25 Impact factor: 3.616

3. Regulation of p130(Cas)/BCAR1 expression in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells by EGR1 and NAB2.

Authors: Joerg Kumbrink; Kathrin H Kirsch
Journal: Neoplasia Date: 2012-02 Impact factor: 5.715

Review 4. Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response.

Authors: Rebecca B Riggins; Mary M Mazzotta; Omar Z Maniya; Robert Clarke
Journal: Endocr Relat Cancer Date: 2010-08-16 Impact factor: 5.678

5. Guidelines for the welfare and use of animals in cancer research.

Authors: P Workman; E O Aboagye; F Balkwill; A Balmain; G Bruder; D J Chaplin; J A Double; J Everitt; D A H Farningham; M J Glennie; L R Kelland; V Robinson; I J Stratford; G M Tozer; S Watson; S R Wedge; S A Eccles
Journal: Br J Cancer Date: 2010-05-25 Impact factor: 7.640

Review 10. Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development.

Authors: Jacqueline Whyte; Orla Bergin; Alessandro Bianchi; Sara McNally; Finian Martin
Journal: Breast Cancer Res Date: 2009 Impact factor: 6.466