| Literature DB >> 16674054 |
Nicolas Marion1, Elise C Ecarnot, Oscar Navarro, Dino Amoroso, Andrew Bell, Steven P Nolan.
Abstract
A very straightforward synthesis of (IPr)Pd(acac)Cl from two commercially available starting materials, Pd(acac)2 and IPr.HCl [acac = acetylacetonate; IPr = N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene], has been developed. The resulting complex, (IPr)Pd(acac)Cl (1), has proven to be a highly active PdII precatalyst in the Buchwald-Hartwig and the alpha-ketone arylation reactions. A wide range of substrates has been screened, including unactivated, sterically hindered, and heterocyclic aryl chlorides.Entities:
Year: 2006 PMID： 16674054 DOI： 10.1021/jo060190h
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354