Literature DB >> 1667316

In-target production of [13N]ammonia via proton irradiation of dilute aqueous ethanol and acetic acid mixtures.

B Wieland1, G Bida, H Padgett, G Hendry, E Zippi, G Kabalka, J L Morelle, R Verbruggen, M Ghyoot.   

Abstract

A reliable, reproducible method has been developed for the in situ production of decicurie quantities of [13N]ammonia by proton irradiation of pressurized, dilute aqueous solutions of acetic acid and ethanol. Some of the parameters investigated for their effect on the 13N product distribution included dose, dose rate, solute concentration, target body material, beam strike volume and proton energy. For the conditions investigated, [13N]NH3 was produced directly in the target in yields greater than 75%.

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Year:  1991        PMID： 1667316     DOI： 10.1016/0883-2889(91)90018-v

Source DB:  PubMed          Journal:  Int J Rad Appl Instrum A        ISSN： 0883-2889


  9 in total

1.  Characterizing the normal range of myocardial blood flow with ⁸²rubidium and ¹³N-ammonia PET imaging.

Authors:  Jennifer M Renaud; Jean N DaSilva; Rob S B Beanlands; Robert A DeKemp
Journal:  J Nucl Cardiol       Date:  2013-05-09       Impact factor: 5.952

2.  Metabolism of nitrogen-13 labelled ammonia in different conditions in dogs, human volunteers and transplant patients.

Authors:  G Bormans; A Maes; W Langendries; J Nuyts; M Vrolix; J Vanhaecke; C Schiepers; M De Roo; L Mortelmans; A Verbruggen
Journal:  Eur J Nucl Med       Date:  1995-02

3.  Quantification of myocardial blood flow with 82Rb dynamic PET imaging.

Authors:  Mireille Lortie; Rob S B Beanlands; Keiichiro Yoshinaga; Ran Klein; Jean N Dasilva; Robert A DeKemp
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-07-07       Impact factor: 9.236

4.  Is planar thallium-201/fluorine-18 fluorodeoxyglucose imaging a reasonable clinical alternative to positron emission tomographic myocardial viability scanning?

Authors:  V Kalff; S U Berlangieri; B Van Every; J L Rowe; R M Lambrecht; H J Tochon-Danguy; G F Egan; W J McKay; M J Kelly
Journal:  Eur J Nucl Med       Date:  1995-07

5.  Determination of radionuclides and radiochemical impurities produced by in-house cyclotron irradiation and subsequent radiosynthesis of PET tracers.

Authors:  Kiichi Ishiwata; Kunpei Hayashi; Masanari Sakai; Sugio Kawauchi; Hideaki Hasegawa; Jun Toyohara
Journal:  Ann Nucl Med       Date:  2016-10-15       Impact factor: 2.668

6.  Convergent synthesis of 13N-labelled Peptidic structures using aqueous [13N]NH3.

Authors:  Julia E Blower; Samuel F Cousin; Antony D Gee
Journal:  EJNMMI Radiopharm Chem       Date:  2017-12-19

7.  Evaluation of [13N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain.

Authors:  Alice Egerton; Joel T Dunn; Nisha Singh; Zilin Yu; Jim O'Doherty; Ivan Koychev; Jessica Webb; Simon Claridge; Federico E Turkheimer; Paul K Marsden; Alexander Hammers; Antony Gee
Journal:  EJNMMI Res       Date:  2020-12-03       Impact factor: 3.138

8.  Fully Automated Synthesis of Nitrogen-13-NH3 by SHIs HM-18 Cyclotron and Dedicated Module for Routine Clinical Studies: Our Institutional Experiences.

Authors:  Singh K Akhilesh; Nilesh Shanker; Kheruka C Subhash; Gambhir Sanjay; Manish Dixit
Journal:  Indian J Nucl Med       Date:  2022-03-25

9.  Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical production.

Authors:  Christopher Frank; Georg Winter; Fredrik Rensei; Victor Samper; Allen F Brooks; Brian G Hockley; Bradford D Henderson; Christian Rensch; Peter J H Scott
Journal:  EJNMMI Radiopharm Chem       Date:  2019-09-18
  9 in total

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