BACKGROUND: A rare case of a congenital brain neoplasm with intratumoral massive hemorrhage suggested by prenatal ultrasound examination in a 32-week gestational age male fetus is reported. The child died shortly after birth due to cardiorespiratory insufficiency. METHODS: Autopsy disclosed a large well-delimited tumor with a sponge-like appearance due to high vascularization, which involved nearly the whole left cerebral hemisphere and led to marked hydrocephalus by secondary aqueductal stenosis. Histological and immunohistochemical examination confirmed the diagnosis of a malignant glioma with features of a glioblastoma multiforme (GBM) matching well with previous findings in primary pediatric GBMs. FINDINGS: The present case demonstrates that malignant congenital neoplasms should be considered in the differential diagnosis of fetal intracranial hemorrhage.
BACKGROUND: A rare case of a congenital brain neoplasm with intratumoral massive hemorrhage suggested by prenatal ultrasound examination in a 32-week gestational age male fetus is reported. The child died shortly after birth due to cardiorespiratory insufficiency. METHODS: Autopsy disclosed a large well-delimited tumor with a sponge-like appearance due to high vascularization, which involved nearly the whole left cerebral hemisphere and led to marked hydrocephalus by secondary aqueductal stenosis. Histological and immunohistochemical examination confirmed the diagnosis of a malignant glioma with features of a glioblastoma multiforme (GBM) matching well with previous findings in primary pediatric GBMs. FINDINGS: The present case demonstrates that malignant congenital neoplasms should be considered in the differential diagnosis of fetal intracranial hemorrhage.
Authors: Ben G McGahan; Beth K Neilsen; David L Kelly; Rodney D McComb; S A Jaffar Kazmi; Matt L White; Yan Zhang; Michele R Aizenberg Journal: J Neurooncol Date: 2017-01-19 Impact factor: 4.130
Authors: Mehmet Serdar Kutuk; Ali Yikilmaz; Mahmut Tuncay Ozgun; Mehmet Dolanbay; Mehmet Canpolat; Semih Uludag; Gulsum Uysal; Mustafa Tas; Karakukcu Musa Journal: Childs Nerv Syst Date: 2013-08-02 Impact factor: 1.475
Authors: Margaret E Macy; Diane K Birks; Valerie N Barton; Michael H Chan; Andrew M Donson; B K Kleinschmidt-Demasters; Lynne T Bemis; Michael H Handler; Nicholas K Foreman Journal: Neuro Oncol Date: 2012-06-18 Impact factor: 12.300
Authors: Naveen Mehrotra; Mohammed F Shamji; Michael Vassilyadi; Enrique C G Ventureyra Journal: Childs Nerv Syst Date: 2009-06-24 Impact factor: 1.475
Authors: Antonio G Junior; Nina M P Abreu; Marcus Vinícius B Leal; Hilanne L A de Aquino; João Paulo C Rodrigues; Caio B Malveira; Yael P Silva; Pablo P A Coimbra Journal: Cureus Date: 2022-03-16