Literature DB >> 16672625

Evidence that Clostridium difficile TcdC is a membrane-associated protein.

Revathi Govind1, Govindsamy Vediyappan, Rial D Rolfe, Joe A Fralick.   

Abstract

Clostridium difficile produces two toxins, A and B, which act together to cause pseudomembraneous colitis. The genes encoding these toxins, tcdA and tcdB, are part of the pathogenicity locus, which also includes tcdC, a putative negative regulator of the toxin genes. In this study, we demonstrate that TcdC is a membrane-associated protein in C. difficile.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16672625      PMCID： PMC1482853          DOI： 10.1128/JB.188.10.3716-3720.2006

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  20 in total

1.  Characterization of the Escherichia coli sigma E regulon.

Authors:  C Dartigalongue; D Missiakas; S Raina
Journal:  J Biol Chem       Date:  2001-03-23       Impact factor: 5.157

2.  Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor.

Authors:  N Mani; B Dupuy
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-24       Impact factor: 11.205

3.  An epidemic, toxin gene-variant strain of Clostridium difficile.

Authors:  L Clifford McDonald; George E Killgore; Angela Thompson; Robert C Owens; Sophia V Kazakova; Susan P Sambol; Stuart Johnson; Dale N Gerding
Journal:  N Engl J Med       Date:  2005-12-01       Impact factor: 91.245

4.  The toxigenic element of Clostridium difficile strain VPI 10463.

Authors:  G A Hammond; J L Johnson
Journal:  Microb Pathog       Date:  1995-10       Impact factor: 3.738

5.  Treatment of Clostridium difficile colitis.

Authors:  J G Bartlett
Journal:  Gastroenterology       Date:  1985-11       Impact factor: 22.682

6.  Accessibility of F0 subunits from Escherichia coli ATP synthase. A study with subunit specific antisera.

Authors:  G Deckers-Hebestreit; K Altendorf
Journal:  Eur J Biochem       Date:  1986-11-17

Review 7.  Role of toxins A and B in the pathogenesis of Clostridium difficile disease.

Authors:  G P Bongaerts; D M Lyerly
Journal:  Microb Pathog       Date:  1994-07       Impact factor: 3.738

8.  Environmental response and autoregulation of Clostridium difficile TxeR, a sigma factor for toxin gene expression.

Authors:  Nagraj Mani; Dena Lyras; Lisa Barroso; Pauline Howarth; Tracy Wilkins; Julian I Rood; Abraham L Sonenshein; Bruno Dupuy
Journal:  J Bacteriol       Date:  2002-11       Impact factor: 3.490

9.  Genetic characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates by PCR.

Authors:  J S Moncrief; L Zheng; L M Neville; D M Lyerly
Journal:  J Clin Microbiol       Date:  2000-08       Impact factor: 5.948

10.  Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates.

Authors:  Patrizia Spigaglia; Paola Mastrantonio
Journal:  J Clin Microbiol       Date:  2002-09       Impact factor: 5.948
View more
  13 in total

1.  tcdC genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficile.

Authors:  Scott R Curry; Jane W Marsh; Carlene A Muto; Mary M O'Leary; A William Pasculle; Lee H Harrison
Journal:  J Clin Microbiol       Date:  2006-10-11       Impact factor: 5.948

Review 2.  Integration of metabolism and virulence in Clostridium difficile.

Authors:  Laurent Bouillaut; Thomas Dubois; Abraham L Sonenshein; Bruno Dupuy
Journal:  Res Microbiol       Date:  2014-10-15       Impact factor: 3.992

3.  Observations on the Role of TcdE Isoforms in Clostridium difficile Toxin Secretion.

Authors:  Revathi Govind; Leah Fitzwater; Rebekah Nichols
Journal:  J Bacteriol       Date:  2015-05-26       Impact factor: 3.490

Review 4.  Regulation of Clostridioides difficile toxin production.

Authors:  Aritri Majumdar; Revathi Govind
Journal:  Curr Opin Microbiol       Date:  2021-11-12       Impact factor: 7.934

5.  The C-Terminal Domain of Clostridioides difficile TcdC Is Exposed on the Bacterial Cell Surface.

Authors:  Ana M Oliveira Paiva; Leen de Jong; Annemieke H Friggen; Wiep Klaas Smits; Jeroen Corver
Journal:  J Bacteriol       Date:  2020-10-22       Impact factor: 3.490

6.  Genome sequence and characteristics of Lrm1, a prophage from industrial Lactobacillus rhamnosus strain M1.

Authors:  Evelyn Durmaz; Michael J Miller; M Andrea Azcarate-Peril; Stephen P Toon; Todd R Klaenhammer
Journal:  Appl Environ Microbiol       Date:  2008-06-06       Impact factor: 4.792

7.  Clinical Clostridium difficile: clonality and pathogenicity locus diversity.

Authors:  Kate E Dingle; David Griffiths; Xavier Didelot; Jessica Evans; Alison Vaughan; Melina Kachrimanidou; Nicole Stoesser; Keith A Jolley; Tanya Golubchik; Rosalind M Harding; Tim E Peto; Warren Fawley; A Sarah Walker; Mark Wilcox; Derrick W Crook
Journal:  PLoS One       Date:  2011-05-19       Impact factor: 3.240

8.  The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile.

Authors:  Glen P Carter; Gillian R Douce; Revathi Govind; Pauline M Howarth; Kate E Mackin; Janice Spencer; Anthony M Buckley; Ana Antunes; Despina Kotsanas; Grant A Jenkin; Bruno Dupuy; Julian I Rood; Dena Lyras
Journal:  PLoS Pathog       Date:  2011-10-13       Impact factor: 6.823

9.  Clostridium difficile TcdC protein binds four-stranded G-quadruplex structures.

Authors:  Hans C van Leeuwen; Dennis Bakker; Philip Steindel; Ed J Kuijper; Jeroen Corver
Journal:  Nucleic Acids Res       Date:  2013-01-08       Impact factor: 16.971

10.  TcdC does not significantly repress toxin expression in Clostridium difficile 630ΔErm.

Authors:  Dennis Bakker; Wiep Klaas Smits; Ed J Kuijper; Jeroen Corver
Journal:  PLoS One       Date:  2012-08-17       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.