Literature DB >> 16658540

Triparanol Inhibition of Sterol Biosynthesis in Chlorella ellipsoidea.

J T Chan1, G W Patterson.   

Abstract

The sterol composition of C. ellipsoidea was markedly changed when this alga was grown in the presence of 1 mug/g triparanol. Triparanol appears to inhibit the removal of 14alpha-methyl group, the second alkylation at C-24, Delta(7)-reductase, and Delta(8) --> Delta(7)-isomerase. The effect of triparanol in Chlorella is much more diversified than the specific effect originally assigned to it in animals.

Entities:  

Year:  1973        PMID： 16658540      PMCID： PMC366478          DOI： 10.1104/pp.52.3.246

Source DB:  PubMed          Journal:  Plant Physiol        ISSN： 0032-0889            Impact factor:   8.340


  8 in total

1.  Separation of sterol acetates by column and thin-layer argentation chromatography.

Authors:  H E Vroman; C F Cohen
Journal:  J Lipid Res       Date:  1967-03       Impact factor: 5.922

2.  THE SKIN STEROLS OF NORMAL AND TRIPARANOL-TREATED RATS.

Authors:  R B CLAYTON; A N NELSON; I D FRANTZ
Journal:  J Lipid Res       Date:  1963-04       Impact factor: 5.922

3.  Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29.

Authors:  J AVIGAN; D STEINBERG; H E VROMAN; M J THOMPSON; E MOSETTIG
Journal:  J Biol Chem       Date:  1960-11       Impact factor: 5.157

4.  Inhibitors of cholesterol biosynthesis which act at or beyond the mevalonic acid stage.

Authors:  W L Holmes; N W Ditullio
Journal:  Am J Clin Nutr       Date:  1962-04       Impact factor: 7.045

5.  Inhibition of lipid biosynthesis.

Authors:  M E Dempsey
Journal:  Ann N Y Acad Sci       Date:  1968-03-26       Impact factor: 5.691

6.  [Experimental investigations on the liver-cell "toxicity" of triparanol].

Authors:  H F Otto
Journal:  Beitr Pathol       Date:  1971-02

7.  Study of the cellular action of drugs with protozoa. II. Comparative study of the inhibitions induced by hypocholesteremic agents on Ochromonas danica multiplication; annulment by oleic acid.

Authors:  S Aaronson; B Bensky
Journal:  J Protozool       Date:  1965-05

8.  Sterols of Chlorella. II. The Occurrence of an Unusual Sterol Mixture in Chlorella vulgaris.

Authors:  G W Patterson
Journal:  Plant Physiol       Date:  1967-10       Impact factor: 8.340
  8 in total
  5 in total

1.  Techniques for the isolation and identification of steroids in insects and algae.

Authors:  M J Thompson; G W Patterson; S R Dutky; J A Svoboda; J N Kaplanis
Journal:  Lipids       Date:  1980-09       Impact factor: 1.880

2.  Effects of triparanol and AY-9944 upon sterol biosynthesis in Chorella.

Authors:  G W Patterson; P J Doyle; L G Dickson; J T Chan
Journal:  Lipids       Date:  1974-08       Impact factor: 1.880

3.  Inhibition of Sterol Biosynthesis in Chlorella sorokiniana by Triparanol.

Authors:  J T Chan; G W Patterson
Journal:  Plant Physiol       Date:  1974-02       Impact factor: 8.340

4.  Metabolism of 2,4 -3H - 14alpha-methyl -5alpha-ergost - 8-enol and 2,4- 3H- 5 alpha- ergosta-8, 14-dienol in chlorella ellipsoidea.

Authors:  L B Tsai; G W Patterson; C F Cohen
Journal:  Lipids       Date:  1974-12       Impact factor: 1.880

5.  Metabolism of 2,4-3H-14alpha-methyl-5alpha-ergost-8-enol and 2,4-3H-5alpha-ergosta-8,14-dienol in Ochromonas malhamensis.

Authors:  J H Adler; G W Patterson
Journal:  Lipids       Date:  1976-08       Impact factor: 1.880
  5 in total

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