Literature DB >> 1665302

Leukotriene B4 up-regulates IL-6 rather than IL-1 synthesis in human monocytes.

P E Poubelle1, J Stankova, J Grassi, M Rola-Pleszczynski.   

Abstract

Leukotriene B4 (LTB4) preferentially induced IL-6 mRNA accumulation and IL-6 protein release as assessed by ELISA and the B9 cell bioassay. In contrast, minimal IL-1 mRNA or protein was induced by LTB4 either in the absence or presence of muramyl dipeptide. Supernatants of LTB4-treated monocytes consistently showed enhanced thymocyte costimulatory activity and this was abrogated by 75-80% by anti-IL-1 antibody. Baseline production of IL-1 appeared however to be sufficient for a synergistic stimulation of thymocytes in the presence of IL-6. Our results now help clarify that LTB4 stimulated preferentially IL-6 production and that the observed LTB4-induced augmentation in thymocyte responses to monocyte supernatants is due to augmented IL-6 contents in the presence of baseline minimal IL-1 production.

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Year:  1991        PMID： 1665302     DOI： 10.1007/bf01993233

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  14 in total

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