| Literature DB >> 16651729 |
Jung-Hyun Choi1, Byung-Ha Jung, Ok-Hwa Kang, Hyuk Joon Choi, Pil Sang Park, Sun Hee Cho, Youn-Chul Kim, Dong Hwan Sohn, Hyun Park, John Hwa Lee, Dong-Yeul Kwon.
Abstract
The anti-inflammatory and anti-nociceptive effects and sedative activities of the ethyl acetate fraction of Cynanchum paniculatum (EACP) were evaluated in mice and rats by acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, cotton pellet-induced granuloma formation, formalin-induced licking time, acetic acid-induced writhing response, and pentobarbital-induced sleeping time. EACP at a dose of 40 mg/kg significantly exhibited anti-inflammatory activities on acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, and the late phase of formalin-induced licking time. Moreover, it showed anti-nociceptive effects on acetic acid-induced writhing responses and significant sedative effects on pentobarbital-induced sleeping time. The results demonstrated that the anti-nociceptive effects are apparently related to the sedative effects of EACP. These results support the use of Cynanchum paniculatum in relieving inflammatory pain.Entities:
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Year: 2006 PMID： 16651729 DOI： 10.1248/bpb.29.971
Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233