BACKGROUND: To assess whether the premorbid dietary intake of fatty acids, cholesterol, glutamate or antioxidants was associated with the risk of developing amyotrophic lateral sclerosis (ALS). METHODS: Patients referred to our clinic during 2001-2002, who had definite, probable or possible ALS according to El Escorial criteria, without a familial history of ALS, were asked to participate in a case-control study (132 patients and 220 healthy controls). A food-frequency questionnaire was used to assess dietary intake for the nutrients of interest. Multivariate logistic regression analysis was performed with adjustment for confounding factors (sex, age, level of education, energy intake, body mass index and smoking). RESULTS: A high intake of polyunsaturated fatty acid (PUFA) and vitamin E was significantly associated with a reduced risk of developing ALS (PUFA: odds ratio (OR) = 0.4, 95% confidence interval (CI) = 0.2 to 0.7, p = 0.001; vitamin E: OR = 0.4, 95% CI = 0.2 to 0.7, p = 0.001). PUFA and vitamin E appeared to act synergistically, because in a combined analysis the trend OR for vitamin E was further reduced from 0.67 to 0.37 (p = 0.02), and that for PUFA from 0.60 to 0.26 (p = 0.005), with a significant interaction term (p = 0.03). The intake of flavonols, lycopene, vitamin C, vitamin B2, glutamate, calcium or phytoestrogens was not associated with the risk of developing ALS. CONCLUSION: A high intake of PUFAs and vitamin E is associated with a 50-60% decreased risk of developing ALS, and these nutrients appear to act synergistically.
BACKGROUND: To assess whether the premorbid dietary intake of fatty acids, cholesterol, glutamate or antioxidants was associated with the risk of developing amyotrophic lateral sclerosis (ALS). METHODS:Patients referred to our clinic during 2001-2002, who had definite, probable or possible ALS according to El Escorial criteria, without a familial history of ALS, were asked to participate in a case-control study (132 patients and 220 healthy controls). A food-frequency questionnaire was used to assess dietary intake for the nutrients of interest. Multivariate logistic regression analysis was performed with adjustment for confounding factors (sex, age, level of education, energy intake, body mass index and smoking). RESULTS: A high intake of polyunsaturated fatty acid (PUFA) and vitamin E was significantly associated with a reduced risk of developing ALS (PUFA: odds ratio (OR) = 0.4, 95% confidence interval (CI) = 0.2 to 0.7, p = 0.001; vitamin E: OR = 0.4, 95% CI = 0.2 to 0.7, p = 0.001). PUFA and vitamin E appeared to act synergistically, because in a combined analysis the trend OR for vitamin E was further reduced from 0.67 to 0.37 (p = 0.02), and that for PUFA from 0.60 to 0.26 (p = 0.005), with a significant interaction term (p = 0.03). The intake of flavonols, lycopene, vitamin C, vitamin B2, glutamate, calcium or phytoestrogens was not associated with the risk of developing ALS. CONCLUSION: A high intake of PUFAs and vitamin E is associated with a 50-60% decreased risk of developing ALS, and these nutrients appear to act synergistically.
Authors: Marianne J Engelhart; Mirjam I Geerlings; Annemieke Ruitenberg; John C van Swieten; Albert Hofman; Jacqueline C M Witteman; Monique M B Breteler Journal: JAMA Date: 2002-06-26 Impact factor: 56.272
Authors: R M van den Berg-Vos; J Visser; H Franssen; M de Visser; J M B V de Jong; S Kalmijn; J H J Wokke; L H van den Berg Journal: Brain Date: 2003-05 Impact factor: 13.501
Authors: Éilis J O'Reilly; Kjetil Bjornevik; Michael A Schwarzschild; Marjorie L McCullough; Laurence N Kolonel; Loic Le Marchand; Joann E Manson; Alberto Ascherio Journal: Amyotroph Lateral Scler Frontotemporal Degener Date: 2017-12-26 Impact factor: 4.092
Authors: Daniel Cacabelos; Victoria Ayala; Omar Ramírez-Nunez; Ana Belen Granado-Serrano; Jordi Boada; Jose C E Serrano; Rosanna Cabré; Gisela Nadal-Rey; Maria Josep Bellmunt; Isidro Ferrer; Reinald Pamplona; Manuel Portero-Otin Journal: Neuromolecular Med Date: 2014-07-01 Impact factor: 3.843
Authors: Hussni O Mohammed; Simon R Starkey; Korona Stipetic; Thomas J Divers; Brian A Summers; Alexander de Lahunta Journal: J Neuropathol Exp Neurol Date: 2008-12 Impact factor: 3.685
Authors: John E Landers; Lijia Shi; Ting-Jan Cho; Jonathan D Glass; Christopher E Shaw; P Nigel Leigh; Frank Diekstra; Meraida Polak; Ildefonso Rodriguez-Leyva; Stephan Niemann; Bryan J Traynor; Diane McKenna-Yasek; Peter C Sapp; Ammar Al-Chalabi; Anne-Marie A Wills; Robert H Brown Journal: Amyotroph Lateral Scler Date: 2008-10