| Literature DB >> 16644217 |
Christopher Blackburn1, Bing Guan, James Brown, Courtney Cullis, Stephen M Condon, Tracy J Jenkins, Stephane Peluso, Yingchun Ye, Ruth E Gimeno, Sandhya Punreddy, Ying Sun, Hui Wu, Brian Hubbard, Virendar Kaushik, Peter Tummino, Praveen Sanchetti, Dong Yu Sun, Tom Daniels, Effie Tozzo, Suresh K Balani, Prakash Raman.
Abstract
Several potent, cell permeable 4-aryl-dihydropyrimidinones have been identified as inhibitors of FATP4. Lipophilic ester substituents at the 5-position and substitution at the para-position (optimal groups being -NO(2) and CF(3)) of the 4-aryl group led to active compounds. In two cases racemates were resolved and the S enantiomers shown to have higher potencies.Entities:
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Year: 2006 PMID： 16644217 DOI： 10.1016/j.bmcl.2006.03.102
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823