Literature DB >> 16643039

Bioactivity profiling using HPLC/microtiter-plate analysis: application to a New Zealand marine alga-derived fungus, Gliocladium sp.

Gerhard Lang1, Maya I Mitova, Gill Ellis, Sonia van der Sar, Richard K Phipps, John W Blunt, Nicholas J Cummings, Anthony L J Cole, Murray H G Munro.   

Abstract

Using HPLC/microtiter-plate-based generation of activity profiles the extract of a marine alga-derived fungus, identified as Gliocladium sp., was shown to contain the known strongly cytotoxic metabolite 4-keto-clonostachydiol (1) and also clonostachydiol (2) as well as gliotide (3), a new cyclodepsipeptide containing several D-amino acids. The absolute configuration of 1 was elucidated by reduction to 2, and two further oxidized derivatives of clonostachydiol (5, 6) were prepared and evaluated for biological activity.

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Year:  2006        PMID： 16643039     DOI： 10.1021/np0504917

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  14 in total

Review 1.  Survey of marine natural product structure revisions: a synergy of spectroscopy and chemical synthesis.

Authors:  Takashi L Suyama; William H Gerwick; Kerry L McPhail
Journal:  Bioorg Med Chem       Date:  2011-06-12       Impact factor: 3.641

2.  Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4.

Authors:  Moriah Sandy; Andrew Han; John Blunt; Murray Munro; Margo Haygood; Alison Butler
Journal:  J Nat Prod       Date:  2010-06-25       Impact factor: 4.050

3.  UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries.

Authors:  Jin Yang; Qian Liang; Mei Wang; Cynthia Jeffries; David Smithson; Ying Tu; Nidal Boulos; Melissa R Jacob; Anang A Shelat; Yunshan Wu; Ranga Rao Ravu; Richard Gilbertson; Mitchell A Avery; Ikhlas A Khan; Larry A Walker; R Kiplin Guy; Xing-Cong Li
Journal:  J Nat Prod       Date:  2014-03-11       Impact factor: 4.050

4.  Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels.

Authors:  Susanna Zierler; Guangmin Yao; Zheng Zhang; W Cedric Kuo; Peter Pörzgen; Reinhold Penner; F David Horgen; Andrea Fleig
Journal:  J Biol Chem       Date:  2011-09-16       Impact factor: 5.157

5.  Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.

Authors:  Tyler A Johnson; Johann Sohn; Wayne D Inman; Samarkand A Estee; Steven T Loveridge; Helene C Vervoort; Karen Tenney; Junke Liu; Kenny Kean-Hooi Ang; Joseline Ratnam; Walter M Bray; Nadine C Gassner; Young Y Shen; R Scott Lokey; James H McKerrow; Kyria Boundy-Mills; Arif Nukanto; Atit Kanti; Heddy Julistiono; Leonardus B S Kardono; Leonard F Bjeldanes; Phillip Crews
Journal:  J Nat Prod       Date:  2011-11-30       Impact factor: 4.050

6.  Antimycobacterial and antileishmanial effects of microfungi isolated from tropical regions in México.

Authors:  Marcela Gamboa-Angulo; Gloria M Molina-Salinas; Manuel Chan-Bacab; Sergio R Peraza-Sánchez; Gabriela Heredia; Susana C de la Rosa-García; Manuela Reyes-Estebanez
Journal:  Parasitol Res       Date:  2012-10-21       Impact factor: 2.289

7.  Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products.

Authors:  Tyler A Johnson; Micaela V C Morgan; Natalie A Aratow; Samarkand A Estee; Koneni V Sashidhara; Steven T Loveridge; Nathaniel L Segraves; Phillip Crews
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

8.  Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations.

Authors:  Sonja L Knowles; Christopher D Roberts; Mario Augustinović; Laura Flores-Bocanegra; Huzefa A Raja; Kimberly N Heath-Borrero; Joanna E Burdette; Joseph O Falkinham Iii; Cedric J Pearce; Nicholas H Oberlies
Journal:  J Nat Prod       Date:  2021-03-25       Impact factor: 4.050

9.  A novel phytomyxean parasite associated with galls on the bull-kelp Durvillaea antarctica (Chamisso) Hariot.

Authors:  Franz Goecke; Jutta Wiese; Alejandra Núñez; Antje Labes; Johannes F Imhoff; Sigrid Neuhauser
Journal:  PLoS One       Date:  2012-09-17       Impact factor: 3.240

10.  The isolation of a new S-methyl benzothioate compound from a marine-derived Streptomyces sp.

Authors:  Nor Ainy Mahyudin; John W Blunt; Anthony L J Cole; Murray H G Munro
Journal:  J Biomed Biotechnol       Date:  2012-01-16
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