| Literature DB >> 16641304 |
Paolo Muratori1, Susan E Sutherland, Luigi Muratori, Alessandro Granito, Marcello Guidi, Georges Pappas, Marco Lenzi, Francesco B Bianchi, Janardan P Pandey.
Abstract
GM and KM allotypes-genetic markers of immunoglobulin (Ig) gamma and kappa chains, respectively-are associated with humoral immunity to several infection- and autoimmunity-related epitopes. We hypothesized that GM and KM allotypes contribute to the generation of autoantibodies to liver/kidney microsomal antigen 1 (LKM1) in hepatitis C virus (HCV)-infected persons. To test this hypothesis, we characterized 129 persons with persistent HCV infection for several GM and KM markers and for anti-LKM1 antibodies. The heterozygous GM 1,3,17 23 5,13,21 phenotype was significantly associated with the prevalence of anti-LKM1 antibodies (odds ratio, 5.13; P=0.002), suggesting its involvement in this autoimmune phenomenon in HCV infection.Entities:
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Year: 2006 PMID： 16641304 PMCID： PMC1472085 DOI： 10.1128/JVI.80.10.5097-5099.2006
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103