Literature DB >> 166387

Viral and cellular DNA synthesis in nuclei from human lymphocytes transformed by Epstein-Barr virus.

W C Benz, J L Strominger.   

Abstract

A DNA-synthesizing system in vitro, using nuclei prepared by treatment of human lymphocytes with the detergent Brij 58, was developed. Nuclei from cultured lymphocytes synthesized DNA for as long as 5 hr, and required ATP, deoxynucleoside triphosphates, magnesium, and a calcium chelator. In nuclei from a partially synchronized line of cultured lymphocytes carrying several hundred copies of the Epstein-Barr viral genome, synthesis in vitro was predominately viral in early S phase and cellular in late S phase. These and other data suggested that the DNA synthesis observed in vitro was predominately replicative.

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Year:  1975        PMID： 166387      PMCID： PMC432769          DOI： 10.1073/pnas.72.6.2413

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Intermediate in SV40 DNA chain growth.

Authors:  G C Fareed; N P Salzman
Journal:  Nat New Biol       Date:  1972-08-30

2.  Epstein-Barr virus: transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes.

Authors:  G Miller; T Shope; H Lisco; D Stitt; M Lipman
Journal:  Proc Natl Acad Sci U S A       Date:  1972-02       Impact factor: 11.205

3.  Replication of viral deoxyribonucleic acid and breakdown of cellular deoxyribonucleic acid in Epstein-Barr virus infection.

Authors:  M Nonoyama; J S Pagano
Journal:  J Virol       Date:  1972-04       Impact factor: 5.103

4.  Detection of Epstein-Barr viral genome in nonproductive cells.

Authors:  M Nonoyama; J S Pagano
Journal:  Nat New Biol       Date:  1971-09-22

5.  Partial purification of the Epstein-Barr virus and some properties of its DNA.

Authors:  H Schulte-Holthausen; H zur Hausen
Journal:  Virology       Date:  1970-03       Impact factor: 3.616

6.  Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines.

Authors:  B M Reedman; G Klein
Journal:  Int J Cancer       Date:  1973-05       Impact factor: 7.396

7.  Dna synthesis in isolated HeLa nuclei. A system for continuation of replication in vivo.

Authors:  H V Hershey; J F Stieber; G C Mueller
Journal:  Eur J Biochem       Date:  1973-04

8.  Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents.

Authors:  A Böyum
Journal:  Scand J Clin Lab Invest Suppl       Date:  1968

9.  Studies on the nuclei of cultured human leukemic lymphoblasts (CCRF-CEM cells): method of isolation.

Authors:  A Takakusu; H Lazarus; M Levine; T A McCoy; G E Foley
Journal:  Exp Cell Res       Date:  1968-01       Impact factor: 3.905

10.  Differential reactivity of human serums with early antigens induced by Epstein-Barr virus.

Authors:  W Henle; G Henle; B A Zajac; G Pearson; R Waubke; M Scriba
Journal:  Science       Date:  1970-07-10       Impact factor: 47.728
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  16 in total

1.  Effects of adenine arabinoside on lymphocytes infected with Epstein-Barr virus.

Authors:  W C Benz; P J Siegel; J Baer
Journal:  J Virol       Date:  1978-09       Impact factor: 5.103

2.  Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase.

Authors:  M V Autieri; K L Fresa; F D Coffman; M E Katz; S Cohen
Journal:  Cell Regul       Date:  1990-12

3.  Impaired nuclear responsiveness to cytoplasmic signals in lymphocytes from elderly humans with depressed proliferative responses.

Authors:  J K Gutowski; J B Innes; M E Weksler; S Cohen
Journal:  J Clin Invest       Date:  1986-07       Impact factor: 14.808

4.  The regulation of DNA synthesis in quiescent lymphocytes by cytoplasmic inhibitors.

Authors:  J K Gutowski; A West; S Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

5.  Induction of DNA synthesis in isolated nuclei by cytoplasmic factors: inhibition by protease inhibitors.

Authors:  R L Wong; J K Gutowski; M Katz; R H Goldfarb; S Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

6.  Bacterial artificial chromosomes establish replication timing and sub-nuclear compartment de novo as extra-chromosomal vectors.

Authors:  Jiao Sima; Daniel A Bartlett; Molly R Gordon; David M Gilbert
Journal:  Nucleic Acids Res       Date:  2018-02-28       Impact factor: 16.971

7.  Does hydroxyurea inhibit DNA replication in mouse cells by more than one mechanism?

Authors:  E Wawra; E Wintersberger
Journal:  Mol Cell Biol       Date:  1983-03       Impact factor: 4.272

8.  Increased rate of RNA synthesis: early reaction of primary mouse kidney cells to infection with polyoma virus of simian virus 40.

Authors:  E Pöckl; E Wintersberger
Journal:  J Virol       Date:  1980-07       Impact factor: 5.103

9.  DNA-histone interaction in the vicinity of replication points.

Authors:  E J Schlaeger; R Knippers
Journal:  Nucleic Acids Res       Date:  1979-02       Impact factor: 16.971

10.  Deoxyribonucleic acid synthesis in isolated nuclei from baby-hamster kidney cells (BHK-21/C13). Characterization of the system.

Authors:  J F Burke; C K Pearson
Journal:  Biochem J       Date:  1979-03-15       Impact factor: 3.857
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