Literature DB >> 166377

Properties of cytoplasmic mutants of Saccharomyces cerevisiae with specific lesions in cytochrome oxidase.

A Tzagoloff, A Akai, R B Needleman.   

Abstract

Two mutants with specific defects in cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase; EC 1.9.3.1) have been isolated from cultures of Saccharomyces cerevisiae exposed to the mutagens ethyl-methane sulfonate and Mn++. The mutations have been shown to be extranuclear by two criteria. The phenotype persists in diploids formed by a cross with a p-o strain of yeast of the opposite mating type. Tetrad analysis indicates a non-Mendelian segregation (4:0 and 0:4) of the mutations. Both mutants show a total absence of cytochrome oxidase activity and of spectral cytochromes a and as. One of the mutants has been shown to be missing a polypeptide synthesized by mitochondria. The migration of this protein on polyacrylamide gels corresponds to the highest-molecular-weight subunit of cytochrome oxidase.

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Year:  1975        PMID： 166377      PMCID： PMC432691          DOI： 10.1073/pnas.72.6.2054

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

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Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

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Authors:  B EPHRUSSI; P P SLONIMSKI; G PERRODIN
Journal:  Biochim Biophys Acta       Date:  1950-11

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Authors:  W Sebald; H Weiss; G Jackl
Journal:  Eur J Biochem       Date:  1972-11-07

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Authors:  T L Mason; G Schatz
Journal:  J Biol Chem       Date:  1973-02-25       Impact factor: 5.157

5.  Cycloheximide resistant incorporation of amino acids into a polypeptide of the cytochrome oxidase of Neurospora crassa.

Authors:  H Weiss; W Sebald; T Bücher
Journal:  Eur J Biochem       Date:  1971-09-13

6.  Assembly of the mitochondrial membrane system. I. Characterization of some enzymes of the inner membrane of yeast mitochondria.

Authors:  A Tzagoloff
Journal:  J Biol Chem       Date:  1969-09-25       Impact factor: 5.157

7.  Assembly of the mitochondrial membrane system. IV. Role of mitochondrial and cytoplasmic protein synthesis in the biosynthesis of the rutamycin-sensitive adenosine triphosphatase.

Authors:  A Tzagoloff
Journal:  J Biol Chem       Date:  1971-05-10       Impact factor: 5.157

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Journal:  J Biol Chem       Date:  1968-10-25       Impact factor: 5.157

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Authors:  E S Goldring; L I Grossman; D Krupnick; D R Cryer; J Marmur
Journal:  J Mol Biol       Date:  1970-09-14       Impact factor: 5.469

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Authors:  D Coen; J Deutsch; P Netter; E Petrochilo; P P Slonimski
Journal:  Symp Soc Exp Biol       Date:  1970
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  16 in total

1.  Nuclear mutants of Neurospora crassa temperature-sensitive for the synthesis of cytochrome aa3. I. Isolation and preliminary characterization.

Authors:  F E Nargang; H Bertrand
Journal:  Mol Gen Genet       Date:  1978-10-25

2.  The mapping of mutations in tRNA and cytochrome oxidase genes located in the cap-par segment of the mitochondrial genome of S. cerevisiae.

Authors:  M K Trembath; G Macino; A Tzagoloff
Journal:  Mol Gen Genet       Date:  1977-12-14

3.  Biogenesis of mitochondria 49 identification and mapping of a new mitochondrial locus (tsr1) which maps within polar region of yeast mitochondrial genome.

Authors:  R J Devenish; K J Englisn; R M Hall; A W Linnase; H B Lukins
Journal:  Mol Gen Genet       Date:  1978-05-31

4.  Mapping of the two mitochondrial antimycin A resistance loci in Saccharomyces cerevisiae.

Authors:  G Michaelis; E Pratje
Journal:  Mol Gen Genet       Date:  1977-11-04

5.  Biogenesis of mitochondria: molecular mapping of the mitochondrial genome of yeast.

Authors:  A W Linnane; H B Lukins; P L Molloy; P Nagley; J Rytka; K S Sriprakash; M K Trembath
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

6.  Temperature-sensitive respiratory-deficient mitochondrial mutations: isolation and genetic mapping.

Authors:  M Bolotin-Fukuhara; G Fay; H Fukuhara
Journal:  Mol Gen Genet       Date:  1977-04-29

7.  Genetic damage during thymidylate starvation in Saccharomyces cerevisiae.

Authors:  B J Barclay; J G Little
Journal:  Mol Gen Genet       Date:  1978-03-20

8.  The genetic map of the mitochondrial genome in yeast: map positions of drug' and mit- markers as revealed from population analyses of rho- clones in Saccharomyces cerevisiae.

Authors:  R J Schweyen; B Weiss-Brummer; B Backhaus; F Kaudewitz
Journal:  Mol Gen Genet       Date:  1978-02-16

9.  Analysis of mitochondrial RNA in Saccharomyces cerevisiae.

Authors:  J Locker; R Morimoto; R M Synenki; M Rabinowitz
Journal:  Curr Genet       Date:  1980-02       Impact factor: 3.886

10.  The yeast nuclear gene MRF1 encodes a mitochondrial peptide chain release factor and cures several mitochondrial RNA splicing defects.

Authors:  H J Pel; C Maat; M Rep; L A Grivell
Journal:  Nucleic Acids Res       Date:  1992-12-11       Impact factor: 16.971
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