| Literature DB >> 16637618 |
Thushara Diyabalanage1, Charles D Amsler, James B McClintock, Bill J Baker.
Abstract
Palmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (UACC-66 LC50 = 0.018 muM) and appears to operate via inhibition (IC50 = 2 nM) of V-ATPase.Entities:
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Year: 2006 PMID： 16637618 DOI： 10.1021/ja0588508
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419