Literature DB >> 16636917

Identification and characterization of the human SCAN domain zinc-finger gene ZNF449.

Kuntian Luo1, Jie Li, Yanhui Cui, Meng Xu, Jian Yuan, Wenwen Tang, Bo Wan, Long Yu.   

Abstract

Zinc-finger proteins play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. In this study, we identified a gene encoding a zinc finger protein named ZNF449, which was isolated from human testis cDNA library and mapped to Xq26.3 by searching the UCSC genomic database. The ZNF449 cDNA consists of 4035 nucleotides and has a 518-amino acids open reading frame. The predicted protein contains a leucine-rich region (LER or SCAN domain) at the N-terminus. At the C-terminus of the protein, there are 7 C(2)H(2) (Cys2-His2) zinc-finger motifs. The expression pattern of ZNF449 showed that it was ubiquitously expressed in 18 human adult tissues. ZNF449 protein was located in the nucleus when overexpressed in cultured cells. These results indicate that ZNF449 is a member of the zinc-finger family and it may function as a transcription factor.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16636917     DOI： 10.1007/s11033-005-3966-0

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.742


  17 in total

1.  The zinc finger-associated SCAN box is a conserved oligomerization domain.

Authors:  A J Williams; S C Blacklow; T Collins
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

Review 2.  New insights into the control of MAP kinase pathways.

Authors:  J English; G Pearson; J Wilsbacher; J Swantek; M Karandikar; S Xu; M H Cobb
Journal:  Exp Cell Res       Date:  1999-11-25       Impact factor: 3.905

3.  The SCAN domain mediates selective oligomerization.

Authors:  C Schumacher; H Wang; C Honer; W Ding; J Koehn; Q Lawrence; C M Coulis; L L Wang; D Ballinger; B R Bowen; S Wagner
Journal:  J Biol Chem       Date:  2000-06-02       Impact factor: 5.157

Review 4.  All in the family: the BTB/POZ, KRAB, and SCAN domains.

Authors:  T Collins; J R Stone; A J Williams
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

5.  Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations.

Authors:  T L Sander; A L Haas; M J Peterson; J F Morris
Journal:  J Biol Chem       Date:  2000-04-28       Impact factor: 5.157

6.  Protein motifs 5. Zinc fingers.

Authors:  A Klug; J W Schwabe
Journal:  FASEB J       Date:  1995-05       Impact factor: 5.191

Review 7.  Transcriptional activation: a complex puzzle with few easy pieces.

Authors:  R Tjian; T Maniatis
Journal:  Cell       Date:  1994-04-08       Impact factor: 41.582

8.  Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2.

Authors:  Hideki Adachi; Masafumi Tsujimoto
Journal:  J Biol Chem       Date:  2002-04-26       Impact factor: 5.157

9.  The sequence of the human genome.

Authors:  J C Venter; M D Adams; E W Myers; P W Li; R J Mural; G G Sutton; H O Smith; M Yandell; C A Evans; R A Holt; J D Gocayne; P Amanatides; R M Ballew; D H Huson; J R Wortman; Q Zhang; C D Kodira; X H Zheng; L Chen; M Skupski; G Subramanian; P D Thomas; J Zhang; G L Gabor Miklos; C Nelson; S Broder; A G Clark; J Nadeau; V A McKusick; N Zinder; A J Levine; R J Roberts; M Simon; C Slayman; M Hunkapiller; R Bolanos; A Delcher; I Dew; D Fasulo; M Flanigan; L Florea; A Halpern; S Hannenhalli; S Kravitz; S Levy; C Mobarry; K Reinert; K Remington; J Abu-Threideh; E Beasley; K Biddick; V Bonazzi; R Brandon; M Cargill; I Chandramouliswaran; R Charlab; K Chaturvedi; Z Deng; V Di Francesco; P Dunn; K Eilbeck; C Evangelista; A E Gabrielian; W Gan; W Ge; F Gong; Z Gu; P Guan; T J Heiman; M E Higgins; R R Ji; Z Ke; K A Ketchum; Z Lai; Y Lei; Z Li; J Li; Y Liang; X Lin; F Lu; G V Merkulov; N Milshina; H M Moore; A K Naik; V A Narayan; B Neelam; D Nusskern; D B Rusch; S Salzberg; W Shao; B Shue; J Sun; Z Wang; A Wang; X Wang; J Wang; M Wei; R Wides; C Xiao; C Yan; A Yao; J Ye; M Zhan; W Zhang; H Zhang; Q Zhao; L Zheng; F Zhong; W Zhong; S Zhu; S Zhao; D Gilbert; S Baumhueter; G Spier; C Carter; A Cravchik; T Woodage; F Ali; H An; A Awe; D Baldwin; H Baden; M Barnstead; I Barrow; K Beeson; D Busam; A Carver; A Center; M L Cheng; L Curry; S Danaher; L Davenport; R Desilets; S Dietz; K Dodson; L Doup; S Ferriera; N Garg; A Gluecksmann; B Hart; J Haynes; C Haynes; C Heiner; S Hladun; D Hostin; J Houck; T Howland; C Ibegwam; J Johnson; F Kalush; L Kline; S Koduru; A Love; F Mann; D May; S McCawley; T McIntosh; I McMullen; M Moy; L Moy; B Murphy; K Nelson; C Pfannkoch; E Pratts; V Puri; H Qureshi; M Reardon; R Rodriguez; Y H Rogers; D Romblad; B Ruhfel; R Scott; C Sitter; M Smallwood; E Stewart; R Strong; E Suh; R Thomas; N N Tint; S Tse; C Vech; G Wang; J Wetter; S Williams; M Williams; S Windsor; E Winn-Deen; K Wolfe; J Zaveri; K Zaveri; J F Abril; R Guigó; M J Campbell; K V Sjolander; B Karlak; A Kejariwal; H Mi; B Lazareva; T Hatton; A Narechania; K Diemer; A Muruganujan; N Guo; S Sato; V Bafna; S Istrail; R Lippert; R Schwartz; B Walenz; S Yooseph; D Allen; A Basu; J Baxendale; L Blick; M Caminha; J Carnes-Stine; P Caulk; Y H Chiang; M Coyne; C Dahlke; A Deslattes Mays; M Dombroski; M Donnelly; D Ely; S Esparham; C Fosler; H Gire; S Glanowski; K Glasser; A Glodek; M Gorokhov; K Graham; B Gropman; M Harris; J Heil; S Henderson; J Hoover; D Jennings; C Jordan; J Jordan; J Kasha; L Kagan; C Kraft; A Levitsky; M Lewis; X Liu; J Lopez; D Ma; W Majoros; J McDaniel; S Murphy; M Newman; T Nguyen; N Nguyen; M Nodell; S Pan; J Peck; M Peterson; W Rowe; R Sanders; J Scott; M Simpson; T Smith; A Sprague; T Stockwell; R Turner; E Venter; M Wang; M Wen; D Wu; M Wu; A Xia; A Zandieh; X Zhu
Journal:  Science       Date:  2001-02-16       Impact factor: 47.728

10.  Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.

Authors:  E J Bellefroid; J C Marine; T Ried; P J Lecocq; M Rivière; C Amemiya; D A Poncelet; P G Coulie; P de Jong; C Szpirer
Journal:  EMBO J       Date:  1993-04       Impact factor: 11.598
View more
  1 in total

1.  Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis.

Authors:  Keita Okada; Atsushi Fukai; Daisuke Mori; Yoko Hosaka; Fumiko Yano; Ung-il Chung; Hiroshi Kawaguchi; Sakae Tanaka; Toshiyuki Ikeda; Taku Saito
Journal:  PLoS One       Date:  2014-12-29       Impact factor: 3.240
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.