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Literature DB >> 16635466

A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays.

Phyllis C Leppert¹, William H Catherino, James H Segars.

Abstract

This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.

Entities: Disease

Mesh：

Year: 2006 PMID： 16635466 PMCID： PMC4143906 DOI： 10.1016/j.ajog.2005.12.059

Source DB: PubMed Journal: Am J Obstet Gynecol ISSN： 0002-9378 Impact factor: 8.661

34 in total

Review 1. Tissue repair, contraction, and the myofibroblast.

Authors: Alexis Desmoulière; Christine Chaponnier; Giulio Gabbiani
Journal: Wound Repair Regen Date: 2005 Jan-Feb Impact factor: 3.617

2. The guinea pig model for uterine leiomyomata: gene-hormone interaction?

Authors: John Tsibris
Journal: Fertil Steril Date: 2004-10 Impact factor: 7.329

Review 3. Uterine fibroids: the elephant in the room.

Authors: Cheryl Lyn Walker; Elizabeth A Stewart
Journal: Science Date: 2005-06-10 Impact factor: 47.728

4. The promise and perils of microarray analysis.

Authors: William H Catherino; Phyllis C Leppert; James H Segars
Journal: Am J Obstet Gynecol Date: 2006-04-27 Impact factor: 8.661

5. Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.

Authors: S N Iyer; G Gurujeyalakshmi; S N Giri
Journal: J Pharmacol Exp Ther Date: 1999-10 Impact factor: 4.030

6. Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen.

Authors: K Kuroda; O Okamoto; H Shinkai
Journal: J Invest Dermatol Date: 1999-05 Impact factor: 8.551

7. Pirfenidone: a novel pharmacological agent that inhibits leiomyoma cell proliferation and collagen production.

Authors: B S Lee; S B Margolin; R A Nowak
Journal: J Clin Endocrinol Metab Date: 1998-01 Impact factor: 5.958

8. Profiling of differentially expressed genes in human uterine leiomyomas.

Authors: E-J Lee; G Kong; S-H Lee; S B Rho; C-S Park; B-G Kim; D-S Bae; J J Kavanagh; J-H Lee
Journal: Int J Gynecol Cancer Date: 2005 Jan-Feb Impact factor: 3.437

9. Gene expression profiling of leiomyoma and myometrial smooth muscle cells in response to transforming growth factor-beta.

Authors: Xiaoping Luo; Li Ding; Jingxia Xu; Nasser Chegini
Journal: Endocrinology Date: 2004-12-16 Impact factor: 4.736

10. Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium.

Authors: Phyllis C Leppert; Thomas Baginski; Cara Prupas; William H Catherino; Susan Pletcher; James H Segars
Journal: Fertil Steril Date: 2004-10 Impact factor: 7.329

71 in total

1. Chlamydia trachomatis Seroprevalence and Ultrasound-Diagnosed Uterine Fibroids in a Large Population of Young African-American Women.

Authors: Kristen R Moore; Jennifer S Smith; Stephen R Cole; Dirk P Dittmer; Victor J Schoenbach; Donna D Baird
Journal: Am J Epidemiol Date: 2018-02-01 Impact factor: 4.897

2. Dysregulated chaperones associated with cell proliferation and negative apoptosis regulation in the uterine leiomyoma.

Authors: Blendi Ura; Federica Scrimin; Giorgio Arrigoni; Michelangelo Aloisio; Lorenzo Monasta; Giuseppe Ricci
Journal: Oncol Lett Date: 2018-03-22 Impact factor: 2.967

3. Analysis of microarray experiments of gene expression profiling.

Authors: Adi L Tarca; Roberto Romero; Sorin Draghici
Journal: Am J Obstet Gynecol Date: 2006-08 Impact factor: 8.661

4. Activating transcription factor 3 gene expression suggests that tissue stress plays a role in leiomyoma development.

Authors: Mark Payson; Minnie Malik; Sarah Siti-Nur Morris; James H Segars; Rebecca Chason; William H Catherino
Journal: Fertil Steril Date: 2008-08-09 Impact factor: 7.329

5. Self-Reported Reproductive Tract Infections and Ultrasound Diagnosed Uterine Fibroids in African-American Women.

Authors: Kristen R Moore; Stephen R Cole; Dirk P Dittmer; Victor J Schoenbach; Jennifer S Smith; Donna D Baird
Journal: J Womens Health (Larchmt) Date: 2015-04-22 Impact factor: 2.681

6. Regulation of adipose oestrogen output by mechanical stress.

Authors: Sagar Ghosh; Keith Ashcraft; Md Jamiul Jahid; Craig April; Cyrus M Ghajar; Jianhua Ruan; Howard Wang; Megan Foster; Daniel C Hughes; Amelie G Ramirez; Tim Huang; Jian-Bing Fan; Yanfen Hu; Rong Li
Journal: Nat Commun Date: 2013 Impact factor: 14.919