PURPOSE: To summarize results of randomized controlled trials (RCTs) evaluating growth, cognitive, neurological, and visual development of term infants supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA). DESIGN AND METHODS: The Boyack and Lookinland Methodological Quality Index (MQI) was used to evaluate data from RCTs identified from multiple data bases. RESULTS: Six of ten studies found the addition of DHA and ARA to have no significant effect on infant development. PRACTICE IMPLICATIONS: More expensive formula with endogenous DHA and ARA is not necessary. Results from longer studies currently underway will be beneficial.
PURPOSE: To summarize results of randomized controlled trials (RCTs) evaluating growth, cognitive, neurological, and visual development of term infants supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA). DESIGN AND METHODS: The Boyack and Lookinland Methodological Quality Index (MQI) was used to evaluate data from RCTs identified from multiple data bases. RESULTS: Six of ten studies found the addition of DHA and ARA to have no significant effect on infant development. PRACTICE IMPLICATIONS: More expensive formula with endogenous DHA and ARA is not necessary. Results from longer studies currently underway will be beneficial.
Authors: Melissa R Miller; Jennifer Seifert; Nancy J Szabo; Michael Clare-Salzler; Marian Rewers; Jill M Norris Journal: Matern Child Nutr Date: 2010-10 Impact factor: 3.092
Authors: Sheila M O'Byrne; Yuko Kako; Richard J Deckelbaum; Inge H Hansen; Krzysztof Palczewski; Ira J Goldberg; William S Blaner Journal: Am J Physiol Endocrinol Metab Date: 2009-12-29 Impact factor: 4.310