BACKGROUND: To examine the association between the polymorphisms of the endothelial nitric oxide synthase (eNOS) gene and the occurrence of non-arteritic anterior ischemic optic neuropathy (NAION). METHODS: We studied 15 patients with NAION (mean age, 62 years; 60% male). We investigated two polymorphisms of the eNOS gene, Glu298Asp polymorphism of exon 7 and T(-786)C polymorphism of the promoter region. The genotype distribution in NAION was compared with the control (mean age, 63 years; 63% male) distribution. RESULTS: There was no significant difference in the genotype distribution of the Glu298Asp polymorphism between the NAION and control groups (P = 1.000), whereas the genotype dis-tribution of the T(-786)C polymorphism varied significantly between the patients with NAION and control subjects (P = 0.002). After adjusting on covariates, individuals with the CC genotype of the T(-786)C polymorphism were more likely to develop NAION compared with those with TT genotype (odds ratio = 0.09: 95% CI 0.01-0.86). CONCLUSIONS: We found an increased prevalence of T(-786)C polymorphism of the eNOS gene in patients with NAION. Our data suggest that the T(-786)C polymorphism of the eNOS gene may be an important risk factor in the development of NAION in Japanese subjects.
BACKGROUND: To examine the association between the polymorphisms of the endothelial nitric oxide synthase (eNOS) gene and the occurrence of non-arteritic anterior ischemic optic neuropathy (NAION). METHODS: We studied 15 patients with NAION (mean age, 62 years; 60% male). We investigated two polymorphisms of the eNOS gene, Glu298Asp polymorphism of exon 7 and T(-786)C polymorphism of the promoter region. The genotype distribution in NAION was compared with the control (mean age, 63 years; 63% male) distribution. RESULTS: There was no significant difference in the genotype distribution of the Glu298Asp polymorphism between the NAION and control groups (P = 1.000), whereas the genotype dis-tribution of the T(-786)C polymorphism varied significantly between the patients with NAION and control subjects (P = 0.002). After adjusting on covariates, individuals with the CC genotype of the T(-786)C polymorphism were more likely to develop NAION compared with those with TT genotype (odds ratio = 0.09: 95% CI 0.01-0.86). CONCLUSIONS: We found an increased prevalence of T(-786)C polymorphism of the eNOS gene in patients with NAION. Our data suggest that the T(-786)C polymorphism of the eNOS gene may be an important risk factor in the development of NAION in Japanese subjects.
Authors: M Nakayama; H Yasue; M Yoshimura; Y Shimasaki; K Kugiyama; H Ogawa; T Motoyama; Y Saito; Y Ogawa; Y Miyamoto; K Nakao Journal: Circulation Date: 1999-06-08 Impact factor: 29.690
Authors: M Yoshimura; H Yasue; M Nakayama; Y Shimasaki; H Ogawa; K Kugiyama; Y Saito; Y Miyamoto; Y Ogawa; T Kaneshige; H Hiramatsu; T Yoshioka; S Kamitani; H Teraoka; K Nakao Journal: J Investig Med Date: 2000-09 Impact factor: 2.895
Authors: R De Caterina; P Libby; H B Peng; V J Thannickal; T B Rajavashisth; M A Gimbrone; W S Shin; J K Liao Journal: J Clin Invest Date: 1995-07 Impact factor: 14.808
Authors: Y Shimasaki; H Yasue; M Yoshimura; M Nakayama; K Kugiyama; H Ogawa; E Harada; T Masuda; W Koyama; Y Saito; Y Miyamoto; Y Ogawa; K Nakao Journal: J Am Coll Cardiol Date: 1998-06 Impact factor: 24.094
Authors: Gian Paolo Rossi; Maurizio Cesari; Mario Zanchetta; Stefania Colonna; Giuseppe Maiolino; Luigi Pedon; Martina Cavallin; Pietro Maiolino; Achille C Pessina Journal: J Am Coll Cardiol Date: 2003-03-19 Impact factor: 24.094