| Literature DB >> 16631753 |
Himadri Roy1, Shalini Bhardwaj, Seppo Ylä-Herttuala.
Abstract
Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF-A, -B, -C, -D, -E, -F and placenta growth factor (PlGF), that bind in a distinct pattern to three structurally related receptor tyrosine kinases, denoted VEGF receptor-1, -2, and -3. VEGF-C and VEGF-D also play a crucial role in the process of lymphangiogenesis. Here, we review the biology of VEGFs and evaluate their role in pathological angiogenesis and lymphangiogenesis.Entities:
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Year: 2006 PMID： 16631753 DOI： 10.1016/j.febslet.2006.03.087
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124