Yea Eun Kang1, Koon Soon Kim1, Sung Jae Park2, Seung-Nam Jung2, Jae Won Chang2, Shinae Yi1, Min Gyu Jung3, Jin-Man Kim4, Bon Seok Koo5. 1. Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea. 2. Department of Otolaryngology-Head and Neck Surgery, Research Institute for Medical Sciences, Chungnam National University School of Medicine, 266 Munhwa-ro, Jung-gu, Daejeon, 301-721, Republic of Korea. 3. Department of Pathology and Medical Sciences, Chungnam National University School of Medicine, 266, Munhwa-ro, Jung-gu, Daejeon, 301-721, Republic of Korea. 4. Department of Pathology and Medical Sciences, Chungnam National University School of Medicine, 266, Munhwa-ro, Jung-gu, Daejeon, 301-721, Republic of Korea. jinmank@cnu.ac.kr. 5. Department of Otolaryngology-Head and Neck Surgery, Research Institute for Medical Sciences, Chungnam National University School of Medicine, 266 Munhwa-ro, Jung-gu, Daejeon, 301-721, Republic of Korea. bskoo515@cnu.ac.kr.
Abstract
BACKGROUND: We investigated the expression of angiopoietins in patients with papillary thyroid carcinoma (PTC) and the role of angiopoietins as biomarkers predicting the aggressiveness of PTC. METHODS: Expression of angiopoietins was evaluated by immunohistochemistry of tumor specimens from patients with PTC. We demonstrated potential correlations between expression of angiopoietins and clinicopathologic features. RESULTS: High expression of Ang-1 was positively correlated with a tumor size >1 cm, capsular invasion, extrathyroid extension, lymphovascular invasion, lymph node metastasis, and recurrence (P < 0.05). Moreover, multivariate analysis revealed that high expression of Ang-1 was an independent risk factor for lymph node metastasis (P < 0.001, odds ratio [OR] = 62.113) and lymphovascular invasion (P = 0.027, OR 4.405). However, there was no significant correlation between Ang-2 and clinicopathologic features. CONCLUSIONS: Our results suggest that Ang-1 can serve as a valuable prognostic biomarker for lymph node metastasis and invasiveness in patients with PTC.
BACKGROUND: We investigated the expression of angiopoietins in patients with papillary thyroid carcinoma (PTC) and the role of angiopoietins as biomarkers predicting the aggressiveness of PTC. METHODS: Expression of angiopoietins was evaluated by immunohistochemistry of tumor specimens from patients with PTC. We demonstrated potential correlations between expression of angiopoietins and clinicopathologic features. RESULTS: High expression of Ang-1 was positively correlated with a tumor size >1 cm, capsular invasion, extrathyroid extension, lymphovascular invasion, lymph node metastasis, and recurrence (P < 0.05). Moreover, multivariate analysis revealed that high expression of Ang-1 was an independent risk factor for lymph node metastasis (P < 0.001, odds ratio [OR] = 62.113) and lymphovascular invasion (P = 0.027, OR 4.405). However, there was no significant correlation between Ang-2 and clinicopathologic features. CONCLUSIONS: Our results suggest that Ang-1 can serve as a valuable prognostic biomarker for lymph node metastasis and invasiveness in patients with PTC.
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