Literature DB >> 16630029

Genetic control of immune-mediated necrosis of Mycobacterium avium granulomas.

Manuela Flórido1, Rui Appelberg.   

Abstract

Intravenous infection of C57BL/6 and C57BL/10 mice with low doses of a highly virulent strain of Mycobacterium avium (ATCC 25291) led to the development of granulomas that underwent necrosis. In contrast, neither BALB/c nor DBA/1 mice developed granuloma necrosis after such infection despite a similar course of mycobacterial proliferation. Studies with C57BL/10 mice congenic for the Hc locus revealed that an intact complement C5 gene is required for granuloma necrosis. On the other hand, genetic disruption of the interleukin-10 gene in BALB/c mice made this strain susceptible to granuloma necrosis.

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Year:  2006        PMID: 16630029      PMCID: PMC1782273          DOI: 10.1111/j.1365-2567.2006.02350.x

Source DB:  PubMed          Journal:  Immunology        ISSN: 0019-2805            Impact factor:   7.397


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