| Literature DB >> 16630029 |
Manuela Flórido1, Rui Appelberg.
Abstract
Intravenous infection of C57BL/6 and C57BL/10 mice with low doses of a highly virulent strain of Mycobacterium avium (ATCC 25291) led to the development of granulomas that underwent necrosis. In contrast, neither BALB/c nor DBA/1 mice developed granuloma necrosis after such infection despite a similar course of mycobacterial proliferation. Studies with C57BL/10 mice congenic for the Hc locus revealed that an intact complement C5 gene is required for granuloma necrosis. On the other hand, genetic disruption of the interleukin-10 gene in BALB/c mice made this strain susceptible to granuloma necrosis.Entities:
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Year: 2006 PMID: 16630029 PMCID: PMC1782273 DOI: 10.1111/j.1365-2567.2006.02350.x
Source DB: PubMed Journal: Immunology ISSN: 0019-2805 Impact factor: 7.397