| Literature DB >> 11207301 |
A Wangoo1, T Sparer, I N Brown, V A Snewin, R Janssen, J Thole, H T Cook, R J Shaw, D B Young.
Abstract
Mice that had received adoptive transfer of DO11.10 TCR transgenic T cells polarized toward a Th1 or a Th2 phenotype were challenged with Ag-coated beads or with recombinant Mycobacterium tuberculosis expressing the OVA determinant. The resulting bead-induced pulmonary granulomas reflected the phenotype of the adoptively transferred T cells, with the Th2 cells promoting a fibrotic reaction. Mice receiving Th1 cells mounted an epitope-specific protective response to challenge with recombinant M. tuberculosis. Th2 recipients were characterized by enhanced weight loss and lung fibrosis during acute high-dose infection. The combination of TCR transgenic T cells and epitope-tagged mycobacteria provides a novel experimental model for investigation of the pathogenesis of tuberculosis.Entities:
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Year: 2001 PMID： 11207301 DOI： 10.4049/jimmunol.166.5.3432
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422