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Literature DB >> 16625153

Lipid rafts: contentious only from simplistic standpoints.

Abstract

The hypothesis that lipid rafts exist in plasma membranes and have crucial biological functions remains controversial. The lateral heterogeneity of proteins in the plasma membrane is undisputed, but the contribution of cholesterol-dependent lipid assemblies to this complex, non-random organization promotes vigorous debate. In the light of recent studies with model membranes, computational modelling and innovative cell biology, I propose an updated model of lipid rafts that readily accommodates diverse views on plasma-membrane micro-organization.

Entities: Chemical

Mesh：

Year: 2006 PMID： 16625153 PMCID： PMC2782566 DOI： 10.1038/nrm1925

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

71 in total

1. Triton promotes domain formation in lipid raft mixtures.

Authors: H Heerklotz
Journal: Biophys J Date: 2002-11 Impact factor: 4.033

2. Liquid domains in vesicles investigated by NMR and fluorescence microscopy.

Authors: S L Veatch; I V Polozov; K Gawrisch; S L Keller
Journal: Biophys J Date: 2004-05 Impact factor: 4.033

3. H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton.

Authors: Sarah J Plowman; Cornelia Muncke; Robert G Parton; John F Hancock
Journal: Proc Natl Acad Sci U S A Date: 2005-10-13 Impact factor: 11.205

4. Cell biology: without a raft.

Authors: Ben Nichols
Journal: Nature Date: 2005-08-04 Impact factor: 49.962

Review 5. Condensed complexes of cholesterol and phospholipids.

Authors: Harden M McConnell; Arun Radhakrishnan
Journal: Biochim Biophys Acta Date: 2003-03-10

6. Effects of farnesol on the physical properties of DMPC membranes.

Authors: Amy C Rowat; Danielle Keller; John H Ipsen
Journal: Biochim Biophys Acta Date: 2005-07-15

7. Condensation of the plasma membrane at the site of T lymphocyte activation.

Authors: Katharina Gaus; Elena Chklovskaia; Barbara Fazekas de St Groth; Wendy Jessup; Thomas Harder
Journal: J Cell Biol Date: 2005-10-03 Impact factor: 10.539

8. Raft partitioning and dynamic behavior of human placental alkaline phosphatase in giant unilamellar vesicles.

Authors: Nicoletta Kahya; Deborah A Brown; Petra Schwille
Journal: Biochemistry Date: 2005-05-24 Impact factor: 3.162

Review 9. A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains.

Authors: Richard G W Anderson; Ken Jacobson
Journal: Science Date: 2002-06-07 Impact factor: 47.728

10. Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells.

Authors: Adam D Douglass; Ronald D Vale
Journal: Cell Date: 2005-06-17 Impact factor: 41.582

282 in total

1. Self-consistent mean-field model for palmitoyloleoylphosphatidylcholine-palmitoyl sphingomyelin-cholesterol lipid bilayers.

Authors: Paul W Tumaneng; Sagar A Pandit; Guijun Zhao; H L Scott
Journal: Phys Rev E Stat Nonlin Soft Matter Phys Date: 2011-03-31

Lipid rafts: contentious only from simplistic standpoints.

1. Triton promotes domain formation in lipid raft mixtures.

2. Liquid domains in vesicles investigated by NMR and fluorescence microscopy.

3. H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton.

4. Cell biology: without a raft.

Review 5. Condensed complexes of cholesterol and phospholipids.

6. Effects of farnesol on the physical properties of DMPC membranes.

7. Condensation of the plasma membrane at the site of T lymphocyte activation.

8. Raft partitioning and dynamic behavior of human placental alkaline phosphatase in giant unilamellar vesicles.

Review 9. A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains.

10. Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells.

1. Self-consistent mean-field model for palmitoyloleoylphosphatidylcholine-palmitoyl sphingomyelin-cholesterol lipid bilayers.

2. Aggregation on a membrane of particles undergoing active exchange with a reservoir.

3. The anti-inflammatory drug indomethacin alters nanoclustering in synthetic and cell plasma membranes.

Review 4. Spatial organization of transmembrane receptor signalling.

5. Mathematical modeling of K-Ras nanocluster formation on the plasma membrane.

6. Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling.

7. Spatiotemporal Analysis of K-Ras Plasma Membrane Interactions Reveals Multiple High Order Homo-oligomeric Complexes.

8. Mixtures of supported and hybrid lipid membranes on heterogeneously modified silica nanoparticles.

9. Raft composition at physiological temperature and pH in the absence of detergents.

Review 10. Membrane rafts and caveolae in cardiovascular signaling.