Literature DB >> 16623763

Identifying susceptibility genes for immunological disorders: patterns, power, and proof.

Robert Plenge1, John D Rioux.   

Abstract

There is a genetic basis to the most common immune-mediated diseases. Identifying disease susceptibility genes, however, has been a challenge. Only a few genes have been consistently replicated across multiple studies. These convincing examples provide insight into a genetic approach to common immune diseases as well as insight into disease pathogenesis. Here, we discuss several important concepts of a genetic study -- patterns, power, and proof -- and why these are germane in testing inherited variation for influence on disease. Recent developments in the fields of human genetics and genomics are overcoming limitations within the field, and we anticipate many exciting discoveries in the near future.

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Year:  2006        PMID： 16623763     DOI： 10.1111/j.0105-2896.2006.00372.x

Source DB:  PubMed          Journal:  Immunol Rev        ISSN： 0105-2896            Impact factor:   12.988


  5 in total

Review 1.  Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

Authors:  Ramnik J Xavier; Alan Huett; John D Rioux
Journal:  Gut       Date:  2008-02-13       Impact factor: 23.059

2.  TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

Authors:  Robert M Plenge; Mark Seielstad; Leonid Padyukov; Annette T Lee; Elaine F Remmers; Bo Ding; Anthony Liew; Houman Khalili; Alamelu Chandrasekaran; Leela R L Davies; Wentian Li; Adrian K S Tan; Carine Bonnard; Rick T H Ong; Anbupalam Thalamuthu; Sven Pettersson; Chunyu Liu; Chao Tian; Wei V Chen; John P Carulli; Evan M Beckman; David Altshuler; Lars Alfredsson; Lindsey A Criswell; Christopher I Amos; Michael F Seldin; Daniel L Kastner; Lars Klareskog; Peter K Gregersen
Journal:  N Engl J Med       Date:  2007-09-05       Impact factor: 91.245

3.  Single nucleotide polymorphisms at the TRAF1/C5 locus are associated with rheumatoid arthritis in a Han Chinese population.

Authors:  Jing Zhu; Dinging Zhang; Fengxia Wu; Fei He; Xiaoqi Liu; Lijun Wu; Bin Zhou; Jianping Liu; Fang Lu; Jian Liu; Ruijun Luo; Wubin Long; Minghui Yang; Shi Ma; Xiaodan Wu; Yi Shi; Tong Wu; Ying Lin; Jiyun Yang; Guohua Yuan; Zhenglin Yang
Journal:  BMC Med Genet       Date:  2011-04-14       Impact factor: 2.103

4.  Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.

Authors:  Manuel A Rivas; Mélissa Beaudoin; Agnes Gardet; Christine Stevens; Yashoda Sharma; Clarence K Zhang; Gabrielle Boucher; Stephan Ripke; David Ellinghaus; Noel Burtt; Tim Fennell; Andrew Kirby; Anna Latiano; Philippe Goyette; Todd Green; Jonas Halfvarson; Talin Haritunians; Joshua M Korn; Finny Kuruvilla; Caroline Lagacé; Benjamin Neale; Ken Sin Lo; Phil Schumm; Leif Törkvist; Marla C Dubinsky; Steven R Brant; Mark S Silverberg; Richard H Duerr; David Altshuler; Stacey Gabriel; Guillaume Lettre; Andre Franke; Mauro D'Amato; Dermot P B McGovern; Judy H Cho; John D Rioux; Ramnik J Xavier; Mark J Daly
Journal:  Nat Genet       Date:  2011-10-09       Impact factor: 38.330

5.  Association of AFF3 Gene Polymorphism rs10865035 with Rheumatoid Arthritis: A Population-Based Case-Control Study on a Pakistani Cohort.

Authors:  Yasir Ali; Suleman Khan; Yangchao Chen; Nadia Farooqi; Zia-Ul Islam; Mehran Akhtar; Aisha Aman; Aftab Ali Shah; Muhsin Jamal; Fazal Jalil
Journal:  Genet Res (Camb)       Date:  2021-05-15       Impact factor: 1.588
  5 in total

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