BACKGROUND: D-dimer and fibrinogen/fibrin degradation products (FDP) levels are elevated in subjects with thromboembolic disorders, and the assays for detection of D-dimer and FDP are used in many laboratories for the investigation of these disorders. The aim of this study was to evaluate the association between the plasma levels of D-dimer and FDP in the investigation of thromboembolic disorders. METHODS: D-dimer and FDP immunoassays were performed in 217 consecutive blood samples from subjects with suspected of thromboembolic disorders by use of Liatest D-dimer and Plasma FDP. RESULTS: FDP results were classified in: <5, 5-20, >20 microg/mL, and D-dimer levels obtained in these groups ranged to 350-1,210 ng/mL, 420-1,960 ng/mL, and 1,190-51,170 ng/mL, respectively. A significant association between D-dimer levels and the reaction times necessary to occur agglutination in latex agglutination test for FDP was observed. CONCLUSIONS: There was an association between plasma levels of D-dimer and FDP. The preliminary determination of FDP levels could be useful because it allows estimating the D-dimer levels before of the automated systems analysis, reducing costs associated to dilutions of plasma samples.
BACKGROUND: D-dimer and fibrinogen/fibrin degradation products (FDP) levels are elevated in subjects with thromboembolic disorders, and the assays for detection of D-dimer and FDP are used in many laboratories for the investigation of these disorders. The aim of this study was to evaluate the association between the plasma levels of D-dimer and FDP in the investigation of thromboembolic disorders. METHODS: D-dimer and FDP immunoassays were performed in 217 consecutive blood samples from subjects with suspected of thromboembolic disorders by use of Liatest D-dimer and Plasma FDP. RESULTS: FDP results were classified in: <5, 5-20, >20 microg/mL, and D-dimer levels obtained in these groups ranged to 350-1,210 ng/mL, 420-1,960 ng/mL, and 1,190-51,170 ng/mL, respectively. A significant association between D-dimer levels and the reaction times necessary to occur agglutination in latex agglutination test for FDP was observed. CONCLUSIONS: There was an association between plasma levels of D-dimer and FDP. The preliminary determination of FDP levels could be useful because it allows estimating the D-dimer levels before of the automated systems analysis, reducing costs associated to dilutions of plasma samples.
Authors: E Oger; C Leroyer; L Bressollette; M Nonent; E Le Moigne; Y Bizais; J Amiral; M Grimaux; J Clavier; P Ill; J F Abgrall; D Mottier Journal: Am J Respir Crit Care Med Date: 1998-07 Impact factor: 21.405
Authors: M J Kovacs; K M MacKinnon; D Anderson; K O'Rourke; M Keeney; C Kearon; J Ginsberg; P S Wells Journal: Br J Haematol Date: 2001-10 Impact factor: 6.998
Authors: Hyun Kyung Kim; Kyoung Rhan Lee; Jeon Ho Yang; Sung Jae Yoo; Sang Won Lee; Hyun-Jung Jang; Sang Jae Park; Young-Soo Moon; Joong-Won Park; Chang-Min Kim Journal: Thromb Res Date: 2003-01-25 Impact factor: 3.944
Authors: C Kearon; J S Ginsberg; J Douketis; M Crowther; P Brill-Edwards; J I Weitz; J Hirsh Journal: Ann Intern Med Date: 2001-07-17 Impact factor: 25.391
Authors: John E Schrecengost; Robin D LeGallo; James C Boyd; Karel G M Moons; Steven L Gonias; C Edward Rose; David E Bruns Journal: Clin Chem Date: 2003-09 Impact factor: 8.327