Literature DB >> 16622291

Hypothalamic regulatory pathways and potential obesity treatment targets.

Erin E Jobst1, Pablo J Enriori, Puspha Sinnayah, Michael A Cowley.   

Abstract

With an ever-growing population of obese people as well as comorbidities associated with obesity, finding effective weight loss strategies is more imperative than ever. One of the challenges in curbing the obesity crisis is designing successful strategies for long-term weight loss and weight-loss maintenance. Currently, weight-loss strategies include promotion of therapeutic lifestyle changes (diet and exercise), pharmacological therapy, and bariatric surgery. This review focuses on several pharmacological targets that activate central nervous system pathways that normally limit food intake and body weight. Though it is likely that no single therapy will prove effective for everyone, this review considers several recent pre-clinical targets, and several compounds that have been in human clinical trials.

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Year:  2006        PMID： 16622291     DOI： 10.1385/endo:29:1:33

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  272 in total

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Journal:  Eur J Pharmacol       Date:  2001-03-02       Impact factor: 4.432

Review 3.  Endogenous cannabinoid system as a modulator of food intake.

Authors:  D Cota; G Marsicano; B Lutz; V Vicennati; G K Stalla; R Pasquali; U Pagotto
Journal:  Int J Obes Relat Metab Disord       Date:  2003-03

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Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739

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Journal:  Epilepsia       Date:  2000       Impact factor: 5.864

6.  The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.

Authors:  Daniela Cota; Giovanni Marsicano; Matthias Tschöp; Yvonne Grübler; Cornelia Flachskamm; Mirjam Schubert; Dorothee Auer; Alexander Yassouridis; Christa Thöne-Reineke; Sylvia Ortmann; Federica Tomassoni; Cristina Cervino; Enzo Nisoli; Astrid C E Linthorst; Renato Pasquali; Beat Lutz; Günter K Stalla; Uberto Pagotto
Journal:  J Clin Invest       Date:  2003-08       Impact factor: 14.808

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Authors:  J T Clark; P S Kalra; W R Crowley; S P Kalra
Journal:  Endocrinology       Date:  1984-07       Impact factor: 4.736

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Journal:  Br J Pharmacol       Date:  2002-06       Impact factor: 8.739

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Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

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Journal:  Nat Med       Date:  2002-10-07       Impact factor: 53.440
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  3 in total

1.  Dietary patterns only partially explain the effect of short sleep duration on the incidence of obesity.

Authors:  Chihiro Nishiura; Jun Noguchi; Hideki Hashimoto
Journal:  Sleep       Date:  2010-06       Impact factor: 5.849

2.  Defective peripheral nerve development is linked to abnormal architecture and metabolic activity of adipose tissue in Nscl-2 mutant mice.

Authors:  Karen Ruschke; Henning Ebelt; Nora Klöting; Thomas Boettger; Kay Raum; Matthias Blüher; Thomas Braun
Journal:  PLoS One       Date:  2009-05-13       Impact factor: 3.240

3.  The Effect of PPARalpha, PPARdelta, PPARgamma, and PPARpan Agonists on Body Weight, Body Mass, and Serum Lipid Profiles in Diet-Induced Obese AKR/J Mice.

Authors:  W Wallace Harrington; Christy S Britt; Joan G Wilson; Naphtali O Milliken; Jane G Binz; David C Lobe; William R Oliver; Michael C Lewis; Diane M Ignar
Journal:  PPAR Res       Date:  2007       Impact factor: 4.964
  3 in total

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