| Literature DB >> 16621576 |
Ivan O Edafiogho1, Kethireddy V V Ananthalakshmi, Samuel B Kombian.
Abstract
The mechanism of anticonvulsant action was evaluated for the benzylamino enaminones. The most potent enaminone in this series was the unsubstituted benzylamine analog (30; methyl 4-benzylamino-6-methyl-2-oxocyclohex-3-en-1-oate) which had an oral effective dose (ED50) in rats of 27 mg/kg against maximal electroshock seizures, and a concentration 10-fold less than this dose depressed excitatory synaptic transmission, and action potential firing in the rat brain in vitro.Entities:
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Year: 2006 PMID： 16621576 DOI： 10.1016/j.bmc.2006.03.049
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641