| Literature DB >> 16621551 |
B Narasimhulu Naidu1, Margaret E Sorenson, John D Matiskella, Wenying Li, Justin B Sausker, Yunhui Zhang, Timothy P Connolly, Kin S Lam, Joanne J Bronson, Michael J Pucci, Hyekyung Yang, Yasutsugu Ueda.
Abstract
Stereoselective reduction of dehydroalanine double bond in nocathiacin I afforded the primary amide 2. Enzymatic hydrolysis of the amide 2 provided the carboxylic acid 3, which upon coupling with a variety of amines furnished amides 4-32. Some of these semi-synthetic derivatives have retained very good antibacterial activity and have improved aqueous solubility.Entities:
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Year: 2006 PMID： 16621551 DOI： 10.1016/j.bmcl.2006.03.079
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823