| Literature DB >> 16619343 |
Seung-Il Jeong1, Wan-Soo Han, Yeon-Hee Yun, Kang-Ju Kim.
Abstract
In a continuing search for compounds with antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), a chloroform extract of roots of Aralia continentalis was found to contain continentalic acid (CA, C(20)H(30)O(2)), a diterpenic acid. This compound exhibited potent activity against standard methicillin-susceptible Staphylococcus aureus (MSSA) as well as clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). It was determined that continentalic acid had minimum inhibitory concentrations (MICs) of approximately 8-16 microg/mL against S. aureus, including the MSSA and MRSA standard strains. Therefore, the results obtained in this study suggest that continentalic acid might have potential as an adjunct in the treatment of antibiotic-resistant bacteria.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16619343 DOI： 10.1002/ptr.1894
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878