Literature DB >> 16615974

Failure to eradicate HIV despite fully successful HAART initiated in the first days of life.

Alessandra Viganò1, Daria Trabattoni, Laura Schneider, Francesco Ottaviani, Antonia Aliffi, Erika Longhi, Stefano Rusconi, Mario Clerici.   

Abstract

Highly active antiretroviral therapy (HAART) started shortly after birth resulted in reversion of human immunodeficiency virus (HIV) plasma viremia, proviral DNA in PBMC, viral culture, and serum HIV antibodies to negative. Discontinuation of HAART 2 years after apparent HIV eradication, however, was followed by virus replication, CD4 decline, and destruction of HIV-specific lymphocytes, epitomizing the impossibility of HIV eradication.

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Year:  2006        PMID： 16615974     DOI： 10.1016/j.jpeds.2005.11.037

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  15 in total

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