OBJECTIVE: To determine if postnatal growth failure exerts an adverse effect on subsequent growth and neurodevelopment. STUDY DESIGN: A secondary analysis of 1018 infants who were enrolled in a randomized, clinical trial of glutamine supplementation was performed to determine whether early provision of parenteral amino acids (AA) is associated with better growth and neurodevelopmental outcomes. Infants were stratified by whether they were provided > or =3 g/kg per day of AA at < or =5 days of life (early; n = 182) or not (late; n = 836). RESULTS: At 36 weeks' postmenstrual age, significant differences were found in weight, length, and head circumference in favor of the infants who received early AA; the odds of having weight less than the 10(th) percentile for age was 4-fold higher for infants in the late group. At 18 months' CA, there were no differences in weight, length, or measures of neurodevelopment between the groups; however, male infants in the late group were twice as likely to have head circumference less than the 10(th) percentile. CONCLUSIONS: Early AA were associated with significantly better growth outcomes at 36 weeks' postmenstrual age, and fewer infants who received early AA were found to have suboptimal head growth at 18 months' CA.
RCT Entities:
OBJECTIVE: To determine if postnatal growth failure exerts an adverse effect on subsequent growth and neurodevelopment. STUDY DESIGN: A secondary analysis of 1018 infants who were enrolled in a randomized, clinical trial of glutamine supplementation was performed to determine whether early provision of parenteral amino acids (AA) is associated with better growth and neurodevelopmental outcomes. Infants were stratified by whether they were provided > or =3 g/kg per day of AA at < or =5 days of life (early; n = 182) or not (late; n = 836). RESULTS: At 36 weeks' postmenstrual age, significant differences were found in weight, length, and head circumference in favor of the infants who received early AA; the odds of having weight less than the 10(th) percentile for age was 4-fold higher for infants in the late group. At 18 months' CA, there were no differences in weight, length, or measures of neurodevelopment between the groups; however, male infants in the late group were twice as likely to have head circumference less than the 10(th) percentile. CONCLUSIONS: Early AA were associated with significantly better growth outcomes at 36 weeks' postmenstrual age, and fewer infants who received early AA were found to have suboptimal head growth at 18 months' CA.
Authors: Rosemary D Higgins; Sherin Devaskar; William W Hay; Richard A Ehrenkranz; Frank R Greer; Kathleen Kennedy; Paula Meier; LuAnn Papile; Michael P Sherman Journal: J Pediatr Date: 2012-01-10 Impact factor: 4.406
Authors: Liset E Elstgeest; Shirley E Martens; Enrico Lopriore; Frans J Walther; Arjan B te Pas Journal: PLoS One Date: 2010-02-03 Impact factor: 3.240
Authors: Cristina T Navarrete; Lisa A Wrage; Waldemar A Carlo; Michele C Walsh; Wade Rich; Marie G Gantz; Abhik Das; Kurt Schibler; Nancy S Newman; Anthony J Piazza; Brenda B Poindexter; Seetha Shankaran; Pablo J Sánchez; Brenda H Morris; Ivan D Frantz; Krisa P Van Meurs; C Michael Cotten; Richard A Ehrenkranz; Edward F Bell; Kristi L Watterberg; Rosemary D Higgins; Shahnaz Duara Journal: J Pediatr Date: 2016-06-22 Impact factor: 4.406
Authors: Julie Bartholomew; Camilia R Martin; Elizabeth Allred; Minghua L Chen; Richard A Ehrenkranz; Olaf Dammann; Alan Leviton Journal: Neonatology Date: 2013-10-30 Impact factor: 4.035
Authors: C J Valentine; S Fernandez; L K Rogers; P Gulati; J Hayes; P Lore; T Puthoff; M Dumm; A Jones; K Collins; J Curtiss; K Hutson; K Clark; S E Welty Journal: J Perinatol Date: 2009-06 Impact factor: 2.521