Cristina T Navarrete1, Lisa A Wrage2, Waldemar A Carlo3, Michele C Walsh4, Wade Rich5, Marie G Gantz2, Abhik Das6, Kurt Schibler7, Nancy S Newman5, Anthony J Piazza8, Brenda B Poindexter9, Seetha Shankaran10, Pablo J Sánchez11, Brenda H Morris12, Ivan D Frantz13, Krisa P Van Meurs14, C Michael Cotten15, Richard A Ehrenkranz16, Edward F Bell17, Kristi L Watterberg18, Rosemary D Higgins19, Shahnaz Duara20. 1. University of Miami Miller School of Medicine, Miami, FL. Electronic address: cnavarrete@med.miami.edu. 2. Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC. 3. Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL. 4. Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH. 5. Division of Neonatology, University of California San Diego, San Diego, CA. 6. Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD. 7. Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH. 8. Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA. 9. Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN. 10. Department of Pediatrics, Wayne State University, Detroit, MI. 11. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX. 12. Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX. 13. Division of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, MA. 14. Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA. 15. Department of Pediatrics, Duke University, Durham, NC. 16. Department of Pediatrics, Yale University School of Medicine, New Haven, CT. 17. Department of Pediatrics, University of Iowa, Iowa City, IA. 18. University of New Mexico Health Sciences Center, Albuquerque, NM. 19. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. 20. University of Miami Miller School of Medicine, Miami, FL.
Abstract
OBJECTIVE: To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age. STUDY DESIGN: We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85%-89%, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91%-95%, n = 408, PMA 26 ± 1 weeks, birth weight840± 191 g) SpO2 target ranges. Anthropometric measures were obtained at birth, postnatal days 7, 14, 21, and 28; then at 32 and 36 weeks PMA; and 18-22 months corrected age. Growth velocities were estimated with the exponential method and analyzed with linear mixed models. Poor growth outcome, defined as weight <10th percentile at 36 weeks PMA and 18-22 months corrected age, was compared across the 2 treatment groups by the use of robust Poisson regression. RESULTS: Growth outcomes including growth at 36 weeks PMA and 18-22 months corrected age, as well as growth velocity were similar in the lower and higher SpO2 target groups. CONCLUSION: Targeting different oxygen saturation ranges between 85% and 95% from birth did not impact growth velocity or reduce growth failure in preterm infants.
RCT Entities:
OBJECTIVE: To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age. STUDY DESIGN: We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85%-89%, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91%-95%, n = 408, PMA 26 ± 1 weeks, birth weight 840 ± 191 g) SpO2 target ranges. Anthropometric measures were obtained at birth, postnatal days 7, 14, 21, and 28; then at 32 and 36 weeks PMA; and 18-22 months corrected age. Growth velocities were estimated with the exponential method and analyzed with linear mixed models. Poor growth outcome, defined as weight <10th percentile at 36 weeks PMA and 18-22 months corrected age, was compared across the 2 treatment groups by the use of robust Poisson regression. RESULTS: Growth outcomes including growth at 36 weeks PMA and 18-22 months corrected age, as well as growth velocity were similar in the lower and higher SpO2 target groups. CONCLUSION: Targeting different oxygen saturation ranges between 85% and 95% from birth did not impact growth velocity or reduce growth failure in preterm infants.
Authors: Nelson Claure; Eduardo Bancalari; Carmen D'Ugard; Leif Nelin; Melanie Stein; Rangasamy Ramanathan; Richard Hernandez; Steven M Donn; Michael Becker; Thomas Bachman Journal: Pediatrics Date: 2010-12-27 Impact factor: 7.124
Authors: Juliann M Di Fiore; Michele Walsh; Lisa Wrage; Wade Rich; Neil Finer; Waldemar A Carlo; Richard J Martin Journal: J Pediatr Date: 2012-06-26 Impact factor: 4.406
Authors: R A Ehrenkranz; N Younes; J A Lemons; A A Fanaroff; E F Donovan; L L Wright; V Katsikiotis; J E Tyson; W Oh; S Shankaran; C R Bauer; S B Korones; B J Stoll; D K Stevenson; L A Papile Journal: Pediatrics Date: 1999-08 Impact factor: 7.124
Authors: Richard A Ehrenkranz; Abhik Das; Lisa A Wrage; Brenda B Poindexter; Rosemary D Higgins; Barbara J Stoll; William Oh Journal: Pediatr Res Date: 2011-06 Impact factor: 3.756
Authors: E Baraldi; S Carra; F Vencato; M Filippone; D Trevisanuto; O Milanesi; M Pinello; V Zanardo; F Zacchello Journal: Eur J Pediatr Date: 1997-11 Impact factor: 3.183
Authors: Ariel A Salas; Waldemar A Carlo; Barbara T Do; Edward F Bell; Abhik Das; Krisa P Van Meurs; Brenda B Poindexter; Seetha Shankaran; Noelle Younge; Kristi L Watterberg; Rosemary D Higgins Journal: J Pediatr Date: 2021-06-19 Impact factor: 6.314