C Coughlan1, F McAuliffe, N Bermingham, N Gleeson. 1. Dept of Obstetrics & Gynaecology (Gynaecological Oncology), Coombe Women's Hospital, Dublin. caroljcoughlan@eircom.net
Abstract
BACKGROUND: Vaginal intraepithelial neoplasia (VAIN) is usually detected in patients with synchronous or antecedent cervical or vulval intraepithelial or invasive cancer. VAIN has the potential to progress to malignancy. AIMS: To determine the incidence and severity and analyse the management of vaginal dysplasia in patients undergoing primary hysterectomy for cervical cancer. METHODS: A retrospective study (1984-1998) identified 210 primary invasive cervical cancers. One-hundred and twenty-three patients had a primary hysterectomy. RESULTS: In follow-up six patients were found to have dyskaryosis in a second vaginal smear. Biopsies in the six patients with colposcopic lesions showed VAIN II (n=2), VAIN III (n=1),VAIN III / possible early invasion (n = 1) and invasive carcinoma (n=2). One patient with recurrent squamous cancer received salvage radiotherapy and one with recurrent adenocarcinoma received high dose progestogens and topical 5-fluorouracil. CONCLUSION: All patients are disease-free at follow-up.
BACKGROUND:Vaginal intraepithelial neoplasia (VAIN) is usually detected in patients with synchronous or antecedent cervical or vulval intraepithelial or invasive cancer. VAIN has the potential to progress to malignancy. AIMS: To determine the incidence and severity and analyse the management of vaginal dysplasia in patients undergoing primary hysterectomy for cervical cancer. METHODS: A retrospective study (1984-1998) identified 210 primary invasive cervical cancers. One-hundred and twenty-three patients had a primary hysterectomy. RESULTS: In follow-up six patients were found to have dyskaryosis in a second vaginal smear. Biopsies in the six patients with colposcopic lesions showed VAIN II (n=2), VAIN III (n=1),VAIN III / possible early invasion (n = 1) and invasive carcinoma (n=2). One patient with recurrent squamous cancer received salvage radiotherapy and one with recurrent adenocarcinoma received high dose progestogens and topical 5-fluorouracil. CONCLUSION: All patients are disease-free at follow-up.
Authors: Francesco Sopracordevole; Francesca Mancioli; Nicolò Clemente; Giovanni De Piero; Monica Buttignol; Giorgio Giorda; Andrea Ciavattini Journal: Medicine (Baltimore) Date: 2015-10 Impact factor: 1.817