Literature DB >> 16610208

Pyrazolopyranopyrimidines as a class of anti-inflammatory agents.

Magdy E A Zaki1, Hanan A Soliman, Ola A Hiekal, Aymn E Rashad.   

Abstract

Pyrazolopyranopyrimidines 6a-c and 8a-c were prepared from the reaction of compounds 4a-c or 7a-c with methylamine or ammonium hydroxide solutions. Treatment of compounds 6a-c or 8a-c with 2-chloroethyl methyl ether afforded their corresponding acyclonucleosides 9a-c or 10a-c, respectively, as a new class of acyclonucleosides. All prepared compounds were tested as anti-inflammatory agents and some of them revealed moderate to potent anti-inflammatory activity.

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Year:  2006        PMID： 16610208     DOI： 10.1515/znc-2006-1-201

Source DB:  PubMed          Journal:  Z Naturforsch C J Biosci        ISSN： 0341-0382


  17 in total

1.  One-pot synthesis, biological evaluation, and docking study of new chromeno-annulated thiopyrano[2,3-c]pyrazoles.

Authors:  Bhagyashri D Parmar; Tushar R Sutariya; Gaurangkumar C Brahmbhatt; Narsidas J Parmar; Rajni Kant; Vivek K Gupta; Prashant R Murumkar; Mayank Kumar Sharma; Mange Ram Yadav
Journal:  Mol Divers       Date:  2016-03-26       Impact factor: 2.943

2.  Organocatalyzed enantioselective synthesis of 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylates.

Authors:  Naresh Ramireddy; Santhi Abbaraju; Cong-Gui Zhao
Journal:  Tetrahedron Lett       Date:  2011-12-14       Impact factor: 2.415

3.  Organocatalyzed synthesis of 2-amino-8-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles.

Authors:  Derong Ding; Cong-Gui Zhao
Journal:  Tetrahedron Lett       Date:  2010-03-03       Impact factor: 2.415

Review 4.  Recent Applications of the Multicomponent Synthesis for Bioactive Pyrazole Derivatives.

Authors:  Diana Becerra; Rodrigo Abonia; Juan-Carlos Castillo
Journal:  Molecules       Date:  2022-07-23       Impact factor: 4.927

5.  A small-molecule screen yields idiotype-specific blockers of neuromyelitis optica immunoglobulin G binding to aquaporin-4.

Authors:  Puay-Wah Phuan; Marc O Anderson; Lukmanee Tradtrantip; Hua Zhang; Joseph Tan; Chiwah Lam; Jeffrey L Bennett; A S Verkman
Journal:  J Biol Chem       Date:  2012-09-18       Impact factor: 5.157

6.  Ethyl 6-amino-5-cyano-4-phenyl-2,4-di-hydro-pyrano[2,3-c]pyrazole-3-carboxyl-ate dimethyl sulfoxide monosolvate.

Authors:  Naresh Sharma; Goutam Brahmachari; Bubun Banerjee; Rajni Kant; Vivek K Gupta
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-06-18

7.  6-Amino-3-methyl-4-(3,4,5-tri-meth-oxy-phen-yl)-2,4-di-hydro-pyrano[2,3-c]pyrazole-5-carbo-nitrile.

Authors:  Naresh Sharma; Goutam Brahmachari; Bubun Banerjee; Rajni Kant; Vivek K Gupta
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-07-23

8.  Organocatalyzed enantioselective synthesis of 6-amino-5-cyanodihydropyrano[2,3-c]pyrazoles.

Authors:  Sanjib Gogoi; Cong-Gui Zhao
Journal:  Tetrahedron Lett       Date:  2009-05-13       Impact factor: 2.415

9.  RuIII@CMC/Fe3O4 hybrid: an efficient, magnetic, retrievable, self-organized nanocatalyst for green synthesis of pyranopyrazole and polyhydroquinoline derivatives.

Authors:  Yang Chen; Zhuan Zhang; Wei Jiang; Mingjuan Zhang; Yiqun Li
Journal:  Mol Divers       Date:  2018-10-29       Impact factor: 2.943

10.  6-Amino-3-methyl-4-(3-nitro-phen-yl)-1-phenyl-1H,4H-pyrano[2,3-c]pyrazole-5-carbonitrile.

Authors:  Ming-Shu Wu; Du-Lin Kong; Xiang-Zhu Zhang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-05-20
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