AIM: To find out whether there is a significant difference in the prevalence of the precore stop codon mutation between HBeAg positive and anti-HBe positive children. METHODS: We investigated a large pediatric population of 155 European children (mean age 10.9 years) with chronic hepatitis B by PCR and direct sequencing. Ninety were HBeAg positive and 65 had seroconversion to anti-HBe. Additionally genotyping was performed. RESULTS: Seventy-four (48%) of the sequenced HBV strains were attributed to genotype D and 81 (52%) to genotype A. In the group of 90 HBeAg positive patients, 2 (2.2%) 1896-G-to-A transitions leading to precore stop codon mutation were found, and in the group of 65 anti-HBe positive children, 5 (7.7%) were identified harbouring HBeAg-minus mutants. The difference was not statistically significant (P = 0.13). CONCLUSIONS: HBeAg minus variants as predominant viral HB strains play a minor role in the course of chronic hepatitis B in European children.
AIM: To find out whether there is a significant difference in the prevalence of the precore stop codon mutation between HBeAg positive and anti-HBe positive children. METHODS: We investigated a large pediatric population of 155 European children (mean age 10.9 years) with chronic hepatitis B by PCR and direct sequencing. Ninety were HBeAg positive and 65 had seroconversion to anti-HBe. Additionally genotyping was performed. RESULTS: Seventy-four (48%) of the sequenced HBV strains were attributed to genotype D and 81 (52%) to genotype A. In the group of 90 HBeAg positive patients, 2 (2.2%) 1896-G-to-A transitions leading to precore stop codon mutation were found, and in the group of 65 anti-HBe positive children, 5 (7.7%) were identified harbouring HBeAg-minus mutants. The difference was not statistically significant (P = 0.13). CONCLUSIONS: HBeAg minus variants as predominant viral HB strains play a minor role in the course of chronic hepatitis B in European children.
Authors: E Orito; M Mizokami; H Sakugawa; K Michitaka; K Ishikawa; T Ichida; T Okanoue; H Yotsuyanagi; S Iino Journal: Hepatology Date: 2001-01 Impact factor: 17.425
Authors: W F Carman; M R Jacyna; S Hadziyannis; P Karayiannis; M J McGarvey; A Makris; H C Thomas Journal: Lancet Date: 1989-09-09 Impact factor: 79.321
Authors: R Fukuda; R Mohammad; S Hamamoto; N Ishimura; S Ishihara; S Akagi; M Watanabe; Y Kinoshita Journal: J Pediatr Gastroenterol Nutr Date: 2001-09 Impact factor: 2.839
Authors: Chi-Jen Chu; Emmet B Keeffe; Steven-Huy Han; Robert P Perrillo; Albert D Min; Consuelo Soldevila-Pico; William Carey; Robert S Brown; Velimir A Luketic; Norah Terrault; Anna S F Lok Journal: Hepatology Date: 2003-09 Impact factor: 17.425
Authors: Ann Söderström; Gunnar Norkrans; Nils Conradi; Marie Krantz; Peter Horal; Magnus Lindh Journal: J Pediatr Gastroenterol Nutr Date: 2002-10 Impact factor: 2.839
Authors: Markus Peck-Radosavljevic; Johann Deutsch; Peter Ferenci; Ivo Graziadei; Harald Hofer; Heidemarie Holzmann; Wolf-Dietrich Huber; Herman Laferl; Andreas Maieron; Rudolf Stauber; Wolfgang Vogel Journal: Wien Klin Wochenschr Date: 2010-05-04 Impact factor: 1.704