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Literature DB >> 16609809

Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging.

Sanjay Kalra¹, Peter Tai, Angela Genge, Douglas L Arnold.

Abstract

Riluzole prolongs survival in amyotrophic lateral sclerosis. The temporal and spatial profile of its effect on the brain is unknown. We used proton magnetic resonance spectroscopic imaging to evaluate the neuronal response to 1 day of riluzole treatment in motor and non-motor regions of the brain. In 10 patients the N-acetylaspartate/total creatine (NAA/Cr) ratio increased in the precentral gyrus and supplementary motor area, but not in the post-central gyrus or parietal lobe. Improvement in cortical neuronal metabolic function in the motor cortex occurs early with riluzole treatment.

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Year: 2006 PMID： 16609809 DOI： 10.1007/s00415-006-0162-7

Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849

11 in total

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18 in total

Review 1. Neuroimaging in amyotrophic lateral sclerosis.

Authors: Sumei Wang; Elias R Melhem; Harish Poptani; John H Woo
Journal: Neurotherapeutics Date: 2011-01 Impact factor: 7.620

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Authors: Bradley R Foerster; Martin G Pomper; Brian C Callaghan; Myria Petrou; Richard A E Edden; Mona A Mohamed; Robert C Welsh; Ruth C Carlos; Peter B Barker; Eva L Feldman
Journal: JAMA Neurol Date: 2013-08 Impact factor: 18.302