Literature DB >> 11310635

Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis.

K Stefan1, E Kunesch, R Benecke, J Classen.   

Abstract

Using transcranial magnetic stimulation, the effect of riluzole (RLZ) on cortical excitability was studied in patients with amyotrophic lateral sclerosis (ALS). Paired-pulse inhibition (PPI) and paired-pulse facilitation (PPF) were reduced. RLZ partially restored deficient PPI in the first of 4 consecutive 3-month periods of testing, but left PPF unchanged. These findings substantiate the view that attenuation of glutamate-related excitotoxicity is an important factor contributing to the beneficial effect of RLZ in ALS.

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Year:  2001        PMID： 11310635

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  15 in total

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