Literature DB >> 1660458

Functional analysis of the regulatory region of the yeast phosphatidylserine synthase gene, PSS.

T Kodaki1, J Nikawa, K Hosaka, S Yamashita.   

Abstract

The upstream region of the PSS gene contains three positive cis-acting elements, upstream activation sequences 1 and 2 (UAS1 and UAS2) and a TATA box. The 5' end of UAS1 occurs between positions -239 and -209, and that of UAS2 is between positions -172 and -164. UAS2 contains 5'-TTCACATG-3' as a core sequence at positions -161 to -154. Mutational analysis revealed that this octamer is responsible for the control of PSS expression by inositol and choline. The TATA box is located at positions -112 to -108. In addition, PSS contains a negative cis-acting sequence between UAS2 and the TATA box.

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Year:  1991        PMID： 1660458      PMCID： PMC212596          DOI： 10.1128/jb.173.24.7992-7995.1991

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  17 in total

1.  Nucleotide sequence and characterization of the yeast PSS gene encoding phosphatidylserine synthase.

Authors:  J Nikawa; Y Tsukagoshi; T Kodaki; S Yamashita
Journal:  Eur J Biochem       Date:  1987-08-17

2.  Phosphatidylinositol synthase from Saccharomyces cerevisiae. Reconstitution, characterization, and regulation of activity.

Authors:  A S Fischl; M J Homann; M A Poole; G M Carman
Journal:  J Biol Chem       Date:  1986-03-05       Impact factor: 5.157

3.  Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes.

Authors:  T Kodaki; S Yamashita
Journal:  J Biol Chem       Date:  1987-11-15       Impact factor: 5.157

4.  Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae.

Authors:  J Nikawa; T Kodaki; S Yamashita
Journal:  J Biol Chem       Date:  1987-04-05       Impact factor: 5.157

5.  The membrane-associated enzyme phosphatidylserine synthase is regulated at the level of mRNA abundance.

Authors:  A M Bailis; M A Poole; G M Carman; S A Henry
Journal:  Mol Cell Biol       Date:  1987-01       Impact factor: 4.272

6.  Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis.

Authors:  J P Hirsch; S A Henry
Journal:  Mol Cell Biol       Date:  1986-10       Impact factor: 4.272

7.  Identification of the upstream activation sequences responsible for the expression and regulation of the PEM1 and PEM2 genes encoding the enzymes of the phosphatidylethanolamine methylation pathway in Saccharomyces cerevisiae.

Authors:  T Kodaki; K Hosaka; J Nikawa; S Yamashita
Journal:  J Biochem       Date:  1991-02       Impact factor: 3.387

8.  Primary structure and product characterization of the Saccharomyces cerevisiae CHO1 gene that encodes phosphatidylserine synthase.

Authors:  K Kiyono; K Miura; Y Kushima; T Hikiji; M Fukushima; I Shibuya; A Ohta
Journal:  J Biochem       Date:  1987-11       Impact factor: 3.387

9.  Biosynthesis of inositol in yeast. Primary structure of myo-inositol-1-phosphate synthase (EC 5.5.1.4) and functional analysis of its structural gene, the INO1 locus.

Authors:  M Dean-Johnson; S A Henry
Journal:  J Biol Chem       Date:  1989-01-15       Impact factor: 5.157

10.  Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site.

Authors:  L Guarente; T Mason
Journal:  Cell       Date:  1983-04       Impact factor: 41.582
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  9 in total

Review 1.  Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae.

Authors:  George M Carman; Susan A Henry
Journal:  J Biol Chem       Date:  2007-11-02       Impact factor: 5.157

Review 2.  Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae.

Authors:  M L Greenberg; J M Lopes
Journal:  Microbiol Rev       Date:  1996-03

Review 3.  The response to inositol: regulation of glycerolipid metabolism and stress response signaling in yeast.

Authors:  Susan A Henry; Maria L Gaspar; Stephen A Jesch
Journal:  Chem Phys Lipids       Date:  2014-01-10       Impact factor: 3.329

4.  Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling.

Authors:  Manuel J Villa-García; Myung Sun Choi; Flora I Hinz; María L Gaspar; Stephen A Jesch; Susan A Henry
Journal:  Mol Genet Genomics       Date:  2010-12-07       Impact factor: 3.291

5.  Casein kinase II phosphorylation of the yeast phospholipid synthesis transcription factor Opi1p.

Authors:  Yu-Fang Chang; George M Carman
Journal:  J Biol Chem       Date:  2006-01-01       Impact factor: 5.157

6.  Analysis of FAS3/ACC regulatory region of Saccharomyces cerevisiae: identification of a functional UASINO and sequences responsible for fatty acid mediated repression.

Authors:  S S Chirala; Q Zhong; W Huang; W al-Feel
Journal:  Nucleic Acids Res       Date:  1994-02-11       Impact factor: 16.971

7.  Regulatory gene INO4 of yeast phospholipid biosynthesis is positively autoregulated and functions as a transactivator of fatty acid synthase genes FAS1 and FAS2 from Saccharomyces cerevisiae.

Authors:  H J Schüller; R Schorr; B Hoffmann; E Schweizer
Journal:  Nucleic Acids Res       Date:  1992-11-25       Impact factor: 16.971

8.  Phosphatidylglycerol Supplementation Alters Mitochondrial Morphology and Cardiolipin Composition.

Authors:  I Chu; Ying-Chih Chen; Ruo-Yun Lai; Jui-Fen Chan; Ya-Hui Lee; Maria Balazova; Yuan-Hao Howard Hsu
Journal:  Membranes (Basel)       Date:  2022-03-31

Review 9.  Formation and regulation of mitochondrial membranes.

Authors:  Laila Cigana Schenkel; Marica Bakovic
Journal:  Int J Cell Biol       Date:  2014-01-22
  9 in total

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