Literature DB >> 1660046

Bactericidal activity of sparfloxacin and ciprofloxacin under anaerobic conditions.

M A Cooper1, J M Andrews, R Wise.   

Abstract

The kill kinetics of sparfloxacin and ciprofloxacin have been investigated under anaerobic conditions against Bacteroides fragilis and Escherichia coli. The results for E. coli were compared with those obtained under aerobic conditions. It was found that the quinolones were bactericidal under anaerobic conditions. This bactericidal activity is inhibited by the presence of chloramphenicol, a known protein synthesis inhibitor. Filamentation was seen with B. fragilis after 2 h exposure to either agent.

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Year:  1991        PMID： 1660046     DOI： 10.1093/jac/28.3.399

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  8 in total

1.  Comparative pharmacodynamics of three newer fluoroquinolones versus six strains of staphylococci in an in vitro model under aerobic and anaerobic conditions.

Authors:  David H Wright; Brent W Gunderson; Laurie B Hovde; Gigi H Ross; Khalid H Ibrahim; John C Rotschafer
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

2.  Responses of wild-type and resistant strains of the hyperthermophilic bacterium Thermotoga maritima to chloramphenicol challenge.

Authors:  Clemente I Montero; Matthew R Johnson; Chung-Jung Chou; Shannon B Conners; Sarah G Geouge; Sabrina Tachdjian; Jason D Nichols; Robert M Kelly
Journal:  Appl Environ Microbiol       Date:  2007-06-08       Impact factor: 4.792

3.  Effect of anaerobic growth on quinolone lethality with Escherichia coli.

Authors:  Muhammad Malik; Syed Hussain; Karl Drlica
Journal:  Antimicrob Agents Chemother       Date:  2006-10-16       Impact factor: 5.191

4.  Pharmacodynamic properties of BAY 12-8039 on gram-positive and gram-negative organisms as demonstrated by studies of time-kill kinetics and postantibiotic effect.

Authors:  F J Boswell; J M Andrews; R Wise
Journal:  Antimicrob Agents Chemother       Date:  1997-06       Impact factor: 5.191

Review 5.  Quinolone activity against anaerobes.

Authors:  P C Appelbaum
Journal:  Drugs       Date:  1999       Impact factor: 9.546

6.  Accumulation of norfloxacin by Bacteroides fragilis.

Authors:  V Ricci; L J Piddock
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

Review 7.  Quinolone activity against anaerobes: microbiological aspects.

Authors:  P C Appelbaum
Journal:  Drugs       Date:  1995       Impact factor: 9.546

8.  Effect of aerobic and anaerobic environments on antistaphylococcal activities of five fluoroquinolones.

Authors:  R A Zabinski; K J Walker; A J Larsson; J A Moody; G W Kaatz; J C Rotschafer
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191
  8 in total

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