Literature DB >> 1660028

Regional mapping of 22 microclones around the adenomatous polyposis coli (APC) locus on chromosome 5q.

G M Hampton1, C Howe, G Leuteritz, H Thomas, W F Bodmer, E Solomon, W G Ballhausen.   

Abstract

A previously described genomic library constructed from microdissected DNA has been used to generate a large number of probes around the adenomatous polyposis coli (APC) gene at 5q22. A total of 202 clones were hybridised directly onto a somatic cell hybrid panel containing two APC-related interstitial deletions. Of 75 microclones that gave clear hybridisation signals, 22 independent clones mapped into the region common to both deletions. In addition, 4/22 of the markers are conserved in rodent DNA. These clones should provide a valuable resource for screening cDNA libraries and cloning the DNA around the APC gene in yeast artificial chromosomes.

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Year:  1991        PMID： 1660028     DOI： 10.1007/bf00204940

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  16 in total

1.  Yeast artificial chromosome libraries containing large inserts from mouse and human DNA.

Authors:  Z Larin; A P Monaco; H Lehrach
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

2.  Toward a physical map of the genome of the nematode Caenorhabditis elegans.

Authors:  A Coulson; J Sulston; S Brenner; J Karn
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

3.  Microdissection of the fragile X region.

Authors:  R N MacKinnon; M C Hirst; M V Bell; J E Watson; U Claussen; H J Ludecke; G Senger; B Horsthemke; K E Davies
Journal:  Am J Hum Genet       Date:  1990-08       Impact factor: 11.025

4.  Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5.

Authors:  Y Nakamura; M Lathrop; M Leppert; M Dobbs; J Wasmuth; E Wolff; M Carlson; E Fujimoto; K Krapcho; T Sears
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

5.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

6.  Localization of the gene for familial adenomatous polyposis on chromosome 5.

Authors:  W F Bodmer; C J Bailey; J Bodmer; H J Bussey; A Ellis; P Gorman; F C Lucibello; V A Murday; S H Rider; P Scambler
Journal:  Nature       Date:  1987 Aug 13-19       Impact factor: 49.962

7.  The gene for familial polyposis coli maps to the long arm of chromosome 5.

Authors:  M Leppert; M Dobbs; P Scambler; P O'Connell; Y Nakamura; D Stauffer; S Woodward; R Burt; J Hughes; E Gardner
Journal:  Science       Date:  1987-12-04       Impact factor: 47.728

8.  Detection of APC region-specific signals by nonisotopic chromosomal in situ suppression (CISS)-hybridization using a microdissection library as a probe.

Authors:  U Trautmann; G Leuteritz; G Senger; U Claussen; W G Ballhausen
Journal:  Hum Genet       Date:  1991-08       Impact factor: 4.132

9.  Microdissection of the Prader-Willi syndrome chromosome region and identification of potential gene sequences.

Authors:  K Buiting; M Neumann; H J Lüdecke; G Senger; U Claussen; J Antich; E Passarge; B Horsthemke
Journal:  Genomics       Date:  1990-03       Impact factor: 5.736

10.  CpG island clones from a deletion encompassing the gene for adenomatous polyposis coli.

Authors:  L Varesco; H J Thomas; S Cottrell; V Murday; S J Fennell; S Williams; S Searle; D Sheer; W F Bodmer; A M Frischauf
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205
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  4 in total

1.  Identification of an alternative 5' untranslated region of the adenomatous polyposis coli gene.

Authors:  S Lambertz; W G Ballhausen
Journal:  Hum Genet       Date:  1993-02       Impact factor: 4.132

2.  A region-specific microdissection library for human chromosome 2p23-p25 and the analysis of an interstitial deletion of 2p23.3-p25.1.

Authors:  J Yu; J Qi; S Tong; F T Kao
Journal:  Hum Genet       Date:  1994-05       Impact factor: 4.132

3.  Loss of heterozygosity in cervical carcinoma: subchromosomal localization of a putative tumor-suppressor gene to chromosome 11q22-q24.

Authors:  G M Hampton; L A Penny; R N Baergen; A Larson; C Brewer; S Liao; R M Busby-Earle; A W Williams; C M Steel; C C Bird
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-19       Impact factor: 11.205

4.  Yeast artificial chromosomes for the molecular analysis of the familial polyposis APC gene region.

Authors:  G M Hampton; J R Ward; S Cottrell; K Howe; H J Thomas; W G Ballhausen; T Jones; D Sheer; E Solomon; A M Frischauf
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-01       Impact factor: 11.205
  4 in total

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