Literature DB >> 16592211

The Acid-Base Properties, Hydrolytic Mechanism, and Susceptibility to O(2) Oxidation of Fe(4)S(4)(SR)(4) Clusters.

T C Bruice1, R Maskiewicz, R Job.   

Abstract

The iron-sulfur cluster compounds Fe(4)S(4)(SR)(4) (-2) [where -SR = -SCH(3), -S-C(CH(3))(3), and -S- CH(2)-CH(CH(3))(2)] have been found to represent the base species of weak acids of pK(a) comparable to that of carboxylic acids. The acid species Fe(4)S(4)(SR)(4)H(-) is most subject to reaction with O(2) and to acid-catalyzed solvolysis, while the base species Fe(4)S(4)(SR)(4) (-2) most readily undergoes ligand exchange. The kinetics for hydrolysis of the isobutyl mercaptide cluster salt has been investigated in detail and a mechanism involving the stepwise process [Formula: see text] has been proposed. The importance of the acid-base equilibria in determining the reactivity of the iron-sulfur clusters and its possible importance as a factor in the determination of the potentials of ferredoxins and high potential iron protein are discussed.

Entities:  

Year:  1975        PMID： 16592211      PMCID： PMC432277          DOI： 10.1073/pnas.72.1.231

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  11 in total

Review 1.  Iron-sulfur proteins: structure and function.

Authors:  W H Orme-Johnson
Journal:  Annu Rev Biochem       Date:  1973       Impact factor: 23.643

2.  The electron paramagnetic resonance of oxidized clostridial ferredoxins.

Authors:  W V Sweeney; A J Bearden; J C Rabinowitz
Journal:  Biochem Biophys Res Commun       Date:  1974-07-10       Impact factor: 3.575

3.  "Super-reduction" of chromatium high-potential iron-sulphur protein in the presence of dimethyl sulphoxide.

Authors:  R Cammack
Journal:  Biochem Biophys Res Commun       Date:  1973-09-18       Impact factor: 3.575

4.  Equivalence of metal centers in the iron-sulfur protein active site analogs (Fe4S4(SR)4)2-.

Authors:  R H Holm; B A Averill; T Herskovitz; R B Frankel; H B Gray; O Siiman; F J Grunthaner
Journal:  J Am Chem Soc       Date:  1974-04-17       Impact factor: 15.419

5.  Synthetic analogs of the active sites of iron-sulfur proteins. V. Proton resonance properties of the tetranuclear clusters (Fe4S4(SR)4). Evidence for dominant contact interactions.

Authors:  R H Holm; W D Phillips; B A Averill; J J Mayerle; T Herskovitz
Journal:  J Am Chem Soc       Date:  1974-04-03       Impact factor: 15.419

6.  Synthetic analogs of the active sites of iron-sulfur proteins. VI. Spectral and redox characteristics of the tetranuclear clusters (Fe4S4(SR)4).2-.

Authors:  B V DePamphilis; B A Averill; T Herskovitz; L Que; R H Holm
Journal:  J Am Chem Soc       Date:  1974-06-26       Impact factor: 15.419

7.  Synthetic analogs of the active sites of iron-sulfur proteins. II. Synthesis and structure of the tetra(mercapto-m 3 -sulfido-iron) clusters, (Fe 4 S 4 (SR) 4 ) 2- .

Authors:  B A Averill; T Herskovitz; R H Holm; J A Ibers
Journal:  J Am Chem Soc       Date:  1973-05-30       Impact factor: 15.419

8.  On pig heart aconitase.

Authors:  S C Kennedy; R Rauner; O Gawron
Journal:  Biochem Biophys Res Commun       Date:  1972-05-26       Impact factor: 3.575

9.  Structure and properties of a synthetic analogue of bacterial iron--sulfur proteins.

Authors:  T Herskovitz; B A Averill; R H Holm; J A Ibers; W D Phillips; J F Weiher
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

10.  Synthetic analogs of the active sites of iron-sulfur proteins. VII. Ligand substitution reactions of the tetranuclear clusters (Fe4S4(SR)4)2- and the structure of ((CH3)4N)2(Fe4S4(SC6H5)4).

Authors:  L Que; M A Bobrik; J A Ibers; R H Holm
Journal:  J Am Chem Soc       Date:  1974-06-26       Impact factor: 15.419
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  8 in total

1.  Formation, spectroscopic characterization, and solution stability of an [Fe4S4]2+ cluster derived from β-cyclodextrin dithiolate.

Authors:  Wayne Lo; Ping Zhang; Chang-Chun Ling; Shaw Huang; R H Holm
Journal:  Inorg Chem       Date:  2012-08-30       Impact factor: 5.165

2.  Cubane-type Fe4S4 clusters with chiral thiolate ligation: formation by ligand substitution, detection of intermediates by 1H NMR, and solid state structures including spontaneous resolution upon crystallization.

Authors:  Wayne Lo; Shaw Huang; Shao-Liang Zheng; R H Holm
Journal:  Inorg Chem       Date:  2011-09-26       Impact factor: 5.165

3.  Dependence of the rates of dissolution of the Fe4S4 clusters of Chromatium vinosum high-potential iron protein and ferredoxin on cluster oxidation state.

Authors:  R Maskiewicz; T C Bruice
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

4.  Role of aromatic residues in stabilization of the [Fe4S4] cluster in high-potential iron proteins (HiPIPs): physical characterization and stability studies of Tyr-19 mutants of Chromatium vinosum HiPIP.

Authors:  A Agarwal; D Li; J A Cowan
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-10       Impact factor: 11.205

5.  Iron-sulfur clusters II: Kinetics of ligand exchange studied on a water-soluble Fe(4)S(4)(SR)(4) cluster.

Authors:  R C Job; T C Bruice
Journal:  Proc Natl Acad Sci U S A       Date:  1975-07       Impact factor: 11.205

6.  Stabilities of cubane type [Fe₄S₄(SR)₄](2-) clusters in partially aqueous media.

Authors:  Wayne Lo; Thomas A Scott; Ping Zhang; Chang-Chun Ling; R H Holm
Journal:  J Inorg Biochem       Date:  2010-12-31       Impact factor: 4.155

7.  Reversible Protonated Resting State of the Nitrogenase Active Site.

Authors:  Christine N Morrison; Thomas Spatzal; Douglas C Rees
Journal:  J Am Chem Soc       Date:  2017-07-26       Impact factor: 15.419

8.  Minimal Heterochiral de Novo Designed 4Fe-4S Binding Peptide Capable of Robust Electron Transfer.

Authors:  J Dongun Kim; Douglas H Pike; Alexei M Tyryshkin; G V T Swapna; Hagai Raanan; Gaetano T Montelione; Vikas Nanda; Paul G Falkowski
Journal:  J Am Chem Soc       Date:  2018-08-29       Impact factor: 16.383
  8 in total

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