Literature DB >> 165902

Differential cytotoxic acitivity of anticollagen serum on rat osteoblasts and fibroblasts in tissue culture.

D Duksin, A Maoz, S Fuchs.   

Abstract

Rat skin fibroblasts grown in tissue culture were lysed by anti-rat-tail collagen serum and antibodies to the ordered collagen-like synthetic polymer (Pro-Gly-Pro)-n. This cytotoxic effect is complement-dependent and occurs only if the fibroblasts were pretreated with trypsin. These anti-sera have very little cytotoxicity on cultured rat osteoblasts. This differential cytotoxicity is not due to differential binding of anticollagen serum to the cells. Both osteoblasts and skin fibroblasts bind the anticollagen serum as was demonstrated by fluorescent immunoglobulin.

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Year:  1975        PMID： 165902     DOI： 10.1016/0092-8674(75)90095-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  6 in total

1.  Cell surface-associated structural proteins in connective tissue cells.

Authors:  P Bornstein; J F Ash
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

2.  Cell cycle dependent expression of a glucose regulated cell surface glycoprotein.

Authors:  B J Keys; M Hoyle; A J Millis
Journal:  In Vitro       Date:  1981-09

3.  Immunologic characterization of the membrane-bound collagen in normal human fibroblasts: identification of a distinct membrane collagen.

Authors:  J R Lichtenstein; E A Bauer; R Hoyt; H J Wedner
Journal:  J Exp Med       Date:  1976-07-01       Impact factor: 14.307

4.  Membrane characteristics of adherent cells dissociated from rheumatoid synovial tissue.

Authors:  T G Abrahamsen; P M Johnson; J B Natvig
Journal:  Clin Exp Immunol       Date:  1977-06       Impact factor: 4.330

5.  Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II.

Authors:  J Holoshitz; A Matitiau; I R Cohen
Journal:  J Clin Invest       Date:  1984-01       Impact factor: 14.808

6.  Pathogenic mechanisms in pulmonary fibrosis: collagen-induced migration inhibition factor production and cytotoxicity mediated by lymphocytes.

Authors:  T C Kravis; A Ahmed; T E Brown; J D Fulmer; R G Crystal
Journal:  J Clin Invest       Date:  1976-11       Impact factor: 14.808
  6 in total

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