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Literature DB >> 16585738

DNA replication during aggregation phase is essential for Myxococcus xanthus development.

Linfong Tzeng¹, Terri N Ellis, Mitchell Singer.

Abstract

Previous studies have demonstrated that fruiting body-derived Myxococcus xanthus myxospores contain two fully replicated copies of its genome, implying developmental control of chromosome replication and septation. In this study, we employ DNA replication inhibitors to determine if chromosome replication is essential to development and the exact time frame in which chromosome replication occurs within the developmental cycle. Our results show that DNA replication during the aggregation phase is essential for developmental progression, implying the existence of a checkpoint that monitors chromosome integrity at the end of the aggregation phase.

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Year: 2006 PMID： 16585738 PMCID： PMC1447012 DOI： 10.1128/JB.188.8.2774-2779.2006

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

25 in total

DNA replication during aggregation phase is essential for Myxococcus xanthus development.

1. Spatial control of cell differentiation in Myxococcus xanthus.

2. Chromosome replication in Myxococcus xanthus.

3. SdeK, a histidine kinase required for Myxococcus xanthus development.

4. Deoxyribonucleic acid synthesis during exponential growth and microcyst formation in Myxococcus xanthus.

5. Induction of cellular morphogenesis in Myxococcus xanthus. I. General description.

6. Sigma54 enhancer binding proteins and Myxococcus xanthus fruiting body development.

7. Mechanism of inhibition of deoxyribonucleic acid synthesis in Escherichia coli by hydroxyurea.

8. Mode of action of novobiocin in Escherichia coli.

9. Induction of sporulation during synchronized chromosome replication in Bacillus subtilis.

10. Deoxyribonucleic acid synthesis during microcyst germination in Myxococcus xanthus.

Review 1. Myxobacteria, polarity, and multicellular morphogenesis.

2. Cell division resets polarity and motility for the bacterium Myxococcus xanthus.

3. The Myxococcus xanthus developmental program can be delayed by inhibition of DNA replication.

4. Error-prone DnaE2 Balances the Genome Mutation Rates in Myxococcus xanthus DK1622.

5. ImuA Facilitates SOS Mutagenesis by Inhibiting RecA-Mediated Activity in Myxococcus xanthus.

6. Tracking of chromosome and replisome dynamics in Myxococcus xanthus reveals a novel chromosome arrangement.