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Literature DB >> 16585509

The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes.

Raul Alvarez-Venegas¹, Monther Sadder, Andrej Hlavacka, Frantisek Baluska, Yuannan Xia, Guoqing Lu, Alexey Firsov, Gautam Sarath, Hideaki Moriyama, Joseph G Dubrovsky, Zoya Avramova.

Abstract

The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.

Entities: Chemical Gene Species

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Year: 2006 PMID： 16585509 PMCID： PMC1458695 DOI： 10.1073/pnas.0600944103

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

36 in total

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Authors: Raul Alvarez-Venegas; Zoya Avramova
Journal: Gene Date: 2002-02-20 Impact factor: 3.688

2. Genetic Control of Flower Development by Homeotic Genes in Antirrhinum majus.

Authors: Z Schwarz-Sommer; P Huijser; W Nacken; H Saedler; H Sommer
Journal: Science Date: 1990-11-16 Impact factor: 47.728

Review 3. New insights into the regulation of protein kinase C and novel phorbol ester receptors.

Authors: D Ron; M G Kazanietz
Journal: FASEB J Date: 1999-10 Impact factor: 5.191

4. The MYST domain acetyltransferase Chameau functions in epigenetic mechanisms of transcriptional repression.

Authors: Aurélie Grienenberger; Benoit Miotto; Thierry Sagnier; Giacomo Cavalli; Vera Schramke; Vincent Geli; Marie Christine Mariol; Hélene Berenger; Yacine Graba; Jacques Pradel
Journal: Curr Biol Date: 2002-04-30 Impact factor: 10.834

5. Regulation of chromatin remodeling by inositol polyphosphates.

Authors: David J Steger; Elizabeth S Haswell; Aimee L Miller; Susan R Wente; Erin K O'Shea
Journal: Science Date: 2002-11-14 Impact factor: 47.728

6. Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein.

Authors: S O'Connell; L Wang; S Robert; C A Jones; R Saint; R S Jones
Journal: J Biol Chem Date: 2001-09-24 Impact factor: 5.157

7. Protein lipid overlay assay.

Authors: Simon Dowler; Gursant Kular; Dario R Alessi
Journal: Sci STKE Date: 2002-04-23

8. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.

Authors: Yasuhiro Mochizuki; Philip W Majerus
Journal: Proc Natl Acad Sci U S A Date: 2003-07-30 Impact factor: 11.205

9. The direct interaction between ASH2, a Drosophila trithorax group protein, and SKTL, a nuclear phosphatidylinositol 4-phosphate 5-kinase, implies a role for phosphatidylinositol 4,5-bisphosphate in maintaining transcriptionally active chromatin.

Authors: Mimi K Cheng; Allen Shearn
Journal: Genetics Date: 2004-07 Impact factor: 4.562

10. Identification of a new polyphosphoinositide in plants, phosphatidylinositol 5-monophosphate (PtdIns5P), and its accumulation upon osmotic stress.

Authors: H J Meijer; C P Berrie; C Iurisci; N Divecha; A Musgrave; T Munnik
Journal: Biochem J Date: 2001-12-01 Impact factor: 3.857

47 in total

Review 1. Plant SET domain-containing proteins: structure, function and regulation.

Authors: Danny W-K Ng; Tao Wang; Mahesh B Chandrasekharan; Rodolfo Aramayo; Sunee Kertbundit; Timothy C Hall
Journal: Biochim Biophys Acta Date: 2007-04-12

2. Arabidopsis ORC1 is a PHD-containing H3K4me3 effector that regulates transcription.

Authors: María de la Paz Sanchez; Crisanto Gutierrez
Journal: Proc Natl Acad Sci U S A Date: 2009-01-26 Impact factor: 11.205

Review 3. Promoting gene expression in plants by permissive histone lysine methylation.

Authors: Christopher I Cazzonelli; Tony Millar; E Jean Finnegan; Barry J Pogson
Journal: Plant Signal Behav Date: 2009-06-02

4. The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought.

Authors: Yong Ding; Hanna Lapko; Ivan Ndamukong; Yuannan Xia; Ayed Al-Abdallat; Sreedevi Lalithambika; Monther Sadder; Abdelaty Saleh; Michael Fromm; Jean-Jack Riethoven; Guoqing Lu; Zoya Avramova
Journal: Plant Signal Behav Date: 2009-11-15

5. The Arabidopsis stem cell factor POLTERGEIST is membrane localized and phospholipid stimulated.

Authors: Jennifer M Gagne; Steven E Clark
Journal: Plant Cell Date: 2010-03-26 Impact factor: 11.277

Review 6. Chromatin configuration as a battlefield in plant-bacteria interactions.

Authors: Ka-Wai Ma; Cristina Flores; Wenbo Ma
Journal: Plant Physiol Date: 2011-08-08 Impact factor: 8.340

7. Two distinct roles of ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1) at promoters and within transcribed regions of ATX1-regulated genes.

Authors: Yong Ding; Zoya Avramova; Michael Fromm
Journal: Plant Cell Date: 2011-01-25 Impact factor: 11.277