| Literature DB >> 16584795 |
A Oliviero1, P Profice, P A Tonali, F Pilato, E Saturno, M Dileone, F Ranieri, V Di Lazzaro.
Abstract
To determine whether aging is associated with changes in excitability of the cerebral cortex, we evaluated the excitability of the motor cortex with transcranial magnetic stimulation (TMS). We compared TMS related measures obtained in a group of young people with those of a group of old people. Motor evoked potential (MEP) amplitude was significantly smaller in older than in younger controls (1.3+/-0.8 mV versus 2.7+/-1.1 mV; p<0.0071). Mean cortical silent period (CSP) duration was shorter in older than in younger controls (87+/-29 ms versus 147+/-39 ms; p<0.0071). SP duration/MEP amplitude ratios were similar in both groups. Our results are consistent with an impaired efficiency of some intracortical circuits in old age.Entities:
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Year: 2006 PMID： 16584795 DOI： 10.1016/j.neures.2006.02.002
Source DB: PubMed Journal: Neurosci Res ISSN： 0168-0102 Impact factor: 3.304