Literature DB >> 16581318

Rapid quantitation of cyclophosphamide metabolites in plasma by liquid chromatography-mass spectrometry.

Thomas F Kalhorn1, William N Howald, Scott Cole, Brian Phillips, Joanne Wang, John T Slattery, Jeannine S McCune.   

Abstract

A method is described for the quantification of two metabolites of cyclophosphamide, specifically 4-hydroxycyclophosphamide (HCy), and carboxyethylphosphoramide mustard (CEPM). Plasma HCy is derivatized to the phenylhydrazone which is quantitated by LC-MS monitoring the chloride adduct of the derivative. The LLOQ based on material applied to the system is approximately 20 fmol. Plasma CEPM concentration is determined using LC-MS with a deuterated internal standard. Both assays have 50-fold dynamic range and require less than 4h to complete. The development of this rapid analytical method makes it feasible to adjust the dose of cyclophosphamide based on the pharmacokinetic disposition of HCy and CEPM in hopes of decreasing nonrelapse mortality in cancer patients.

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Year:  2006        PMID： 16581318     DOI： 10.1016/j.jchromb.2006.03.022

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN： 1570-0232            Impact factor:   3.205


  9 in total

1.  A sensitive and rapid ultra high-performance liquid chromatography with tandem mass spectrometric assay for the simultaneous quantitation of cyclophosphamide and the 4-hydroxycyclophosphamide metabolite in human plasma.

Authors:  O Morgan Hall; Cody J Peer; Courtney D Fitzhugh; William D Figg
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2018-04-10       Impact factor: 3.205

2.  Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis.

Authors:  Melanie S Joy; Mary La; Jinzhao Wang; Arlene S Bridges; Yichun Hu; Susan L Hogan; Reginald F Frye; Joyce Blaisdell; Joyce A Goldstein; Mary Anne Dooley; Kim L R Brouwer; Ronald J Falk
Journal:  Br J Clin Pharmacol       Date:  2012-09       Impact factor: 4.335

3.  A pilot pharmacologic biomarker study in HLA-haploidentical hematopoietic cell transplant recipients.

Authors:  Meagan J Bemer; Mohamed Sorror; Brenda M Sandmaier; Paul V O'Donnell; Jeannine S McCune
Journal:  Cancer Chemother Pharmacol       Date:  2013-08-02       Impact factor: 3.333

4.  Quantification of N, N' N"-triethylenethiophosphoramide, N, N"-triethylenephosphoramide, cyclophosphamide, and 4-hydroxy-cyclophosphamide in microvolume human plasma to support neonatal and pediatric drug studies.

Authors:  Liusheng Huang; Beth Apsel Winger; Vincent Cheah; David Gingrich; Florence Marzan; Ying Lu; Jennifer C Cooper; Francesca Aweeka; Janel Long-Boyle
Journal:  J Chromatogr Open       Date:  2022-06-03

5.  Simultaneous determination of cyclophosphamide and carboxyethylphosphoramide mustard in human plasma using online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS).

Authors:  Feng Bai; Charles H Fraga; Michael Tagen; Paula Schaiquevich; Nikolaus Hagedorn; Clinton F Stewart
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2009-04-24       Impact factor: 3.205

6.  Population pharmacokinetics of cyclophosphamide and metabolites in children with neuroblastoma: a report from the Children's Oncology Group.

Authors:  Jeannine S McCune; David H Salinger; Paolo Vicini; Celeste Oglesby; David K Blough; Julie R Park
Journal:  J Clin Pharmacol       Date:  2008-10-16       Impact factor: 3.126

7.  Exposure-Toxicity Association of Cyclophosphamide and Its Metabolites in Infants and Young Children with Primary Brain Tumors: Implications for Dosing.

Authors:  Olivia Campagne; Bo Zhong; Sreenath Nair; Tong Lin; Jie Huang; Arzu Onar-Thomas; Giles Robinson; Amar Gajjar; Clinton F Stewart
Journal:  Clin Cancer Res       Date:  2019-12-03       Impact factor: 12.531

8.  Posttransplantation cyclophosphamide for prevention of graft-versus-host disease after HLA-matched mobilized blood cell transplantation.

Authors:  Marco Mielcarek; Terry Furlong; Paul V O'Donnell; Barry E Storer; Jeannine S McCune; Rainer Storb; Paul A Carpenter; Mary E D Flowers; Frederick R Appelbaum; Paul J Martin
Journal:  Blood       Date:  2016-01-13       Impact factor: 22.113

9.  Pharmacometabonomic association of cyclophosphamide 4-hydroxylation in hematopoietic cell transplant recipients.

Authors:  Jeannine S McCune; Ryotaro Nakamura; Denis O'Meally; Timothy W Randolph; Brenda M Sandmaier; Aleksandra Karolak; David Hockenbery; Sandi L Navarro
Journal:  Clin Transl Sci       Date:  2022-02-20       Impact factor: 4.438
  9 in total

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