OBJECTIVE: To assess the effect of parity on endovascular trophoblastic invasion in early pregnancy. DESIGN: Observational study. SETTING: Teaching hospital. PATIENT(S): Healthy women at 10-14 weeks of gestation. INTERVENTION(S): Surgical termination of pregnancy for nonmedical reasons. MAIN OUTCOME MEASURE(S): Products of conception were blindly examined histologically with regard to the extent of decidual endovascular trophoblast invasion. RESULT(S): Samples were obtained from 20 nulliparous and 10 parous women. The presence of normal intradecidual endovascular trophoblast invasion was identified with a similar frequency in both groups (P=.28). However, the proportion of decidual vessels with endovascular trophoblast invasion was significantly higher in parous women (60%) compared with nulliparous women (32%, P<.001). CONCLUSION(S): Endovascular trophoblast invasion in early pregnancy is more extensive in parous women who already had an uncomplicated pregnancy than in nulliparous women.
OBJECTIVE: To assess the effect of parity on endovascular trophoblastic invasion in early pregnancy. DESIGN: Observational study. SETTING: Teaching hospital. PATIENT(S): Healthy women at 10-14 weeks of gestation. INTERVENTION(S): Surgical termination of pregnancy for nonmedical reasons. MAIN OUTCOME MEASURE(S): Products of conception were blindly examined histologically with regard to the extent of decidual endovascular trophoblast invasion. RESULT(S): Samples were obtained from 20 nulliparous and 10 parous women. The presence of normal intradecidual endovascular trophoblast invasion was identified with a similar frequency in both groups (P=.28). However, the proportion of decidual vessels with endovascular trophoblast invasion was significantly higher in parous women (60%) compared with nulliparous women (32%, P<.001). CONCLUSION(S): Endovascular trophoblast invasion in early pregnancy is more extensive in parous women who already had an uncomplicated pregnancy than in nulliparous women.
Authors: Stefanie N Hinkle; Paul S Albert; Pauline Mendola; Lindsey A Sjaarda; Edwina Yeung; Nansi S Boghossian; S Katherine Laughon Journal: Paediatr Perinat Epidemiol Date: 2013-12-09 Impact factor: 3.980
Authors: Oisín Huhn; Xiaohui Zhao; Laura Esposito; Ashley Moffett; Francesco Colucci; Andrew M Sharkey Journal: Front Immunol Date: 2021-06-21 Impact factor: 7.561