Literature DB >> 16579875

Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.

Carole Ober1, Lin Pan, Natasha Phillips, Rodney Parry, Lianne M Kurina.   

Abstract

Identifying genes that influence susceptibility to asthma-related and atopy-related phenotypes has been challenging, owing to clinical heterogeneity and a complex underlying genetic architecture that includes both gene-gene and gene-environment interactions. In this article, we report the results of genome-wide linkage and association studies of eight asthma-associated quantitative traits in the Hutterites, a founder population of European descent. Our study revealed significant sex-specific genetic architecture for at least five of these traits, and identified 13 genome-wide significant quantitative trait loci (QTL) by linkage or association that are present in only one of the sexes (nine in males, four in females).

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Mesh：

Year:  2006        PMID： 16579875     DOI： 10.1007/s11882-006-0041-4

Source DB:  PubMed          Journal:  Curr Allergy Asthma Rep        ISSN： 1529-7322            Impact factor:   4.919


  46 in total

1.  Estimation of variance components of quantitative traits in inbred populations.

Authors:  M Abney; M S McPeek; C Ober
Journal:  Am J Hum Genet       Date:  2000-02       Impact factor: 11.025

2.  Genome-wide screen for atopy susceptibility alleles in the Hutterites.

Authors:  C Ober; A Tsalenko; S Willadsen; D Newman; R Daniel; X Wu; J Andal; D Hoki; D Schneider; K True; C Schou; R Parry; N Cox
Journal:  Clin Exp Allergy       Date:  1999-12       Impact factor: 5.018

3.  The genetic dissection of complex traits in a founder population.

Authors:  C Ober; M Abney; M S McPeek
Journal:  Am J Hum Genet       Date:  2001-10-03       Impact factor: 11.025

4.  A high-resolution recombination map of the human genome.

Authors:  Augustine Kong; Daniel F Gudbjartsson; Jesus Sainz; Gudrun M Jonsdottir; Sigurjon A Gudjonsson; Bjorgvin Richardsson; Sigrun Sigurdardottir; John Barnard; Bjorn Hallbeck; Gisli Masson; Adam Shlien; Stefan T Palsson; Michael L Frigge; Thorgeir E Thorgeirsson; Jeffrey R Gulcher; Kari Stefansson
Journal:  Nat Genet       Date:  2002-06-10       Impact factor: 38.330

Review 5.  Sexual dimorphism in mammalian gene expression.

Authors:  John L Rinn; Michael Snyder
Journal:  Trends Genet       Date:  2005-05       Impact factor: 11.639

Review 6.  Asthma genetics 2006: the long and winding road to gene discovery.

Authors:  C Ober; S Hoffjan
Journal:  Genes Immun       Date:  2006-03       Impact factor: 2.676

7.  Variation in the type I interferon gene cluster on 9p21 influences susceptibility to asthma and atopy.

Authors:  A Chan; D L Newman; A M Shon; D H Schneider; S Kuldanek; C Ober
Journal:  Genes Immun       Date:  2006-03       Impact factor: 2.676

8.  Siblings, day-care attendance, and the risk of asthma and wheezing during childhood.

Authors:  T M Ball; J A Castro-Rodriguez; K A Griffith; C J Holberg; F D Martinez; A L Wright
Journal:  N Engl J Med       Date:  2000-08-24       Impact factor: 91.245

9.  Sex differences in the genetic basis of morning serum cortisol levels: genome-wide screen identifies two novel loci specific to women.

Authors:  Lianne M Kurina; Lauren A Weiss; Steven W Graves; Rodney Parry; Gordon H Williams; Mark Abney; Carole Ober
Journal:  J Clin Endocrinol Metab       Date:  2005-06-07       Impact factor: 5.958

10.  Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree.

Authors:  Dina L Newman; Mark Abney; Harvey Dytch; Rodney Parry; Mary Sara McPeek; Carole Ober
Journal:  Hum Mol Genet       Date:  2003-01-15       Impact factor: 6.150
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  10 in total

Review 1.  Gene-environment interactions in human disease: nuisance or opportunity?

Authors:  Carole Ober; Donata Vercelli
Journal:  Trends Genet       Date:  2011-01-07       Impact factor: 11.639

2.  Rising prevalence of asthma is sex-specific in a US farming population.

Authors:  Caroline A Motika; Charalampos Papachristou; Mark Abney; Lucille A Lester; Carole Ober
Journal:  J Allergy Clin Immunol       Date:  2011-08-15       Impact factor: 10.793

3.  A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age.

Authors:  Jaideep Moitra; Carrie Evenoski; Saad Sammani; Raj Wadgaonkar; Jerrold R Turner; Shwu Fan Ma; Joe G N Garcia
Journal:  Transl Res       Date:  2008-01-18       Impact factor: 7.012

4.  A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.

Authors:  Jayant M Pinto; M Geoffrey Hayes; Daniel Schneider; Robert M Naclerio; Carole Ober
Journal:  Laryngoscope       Date:  2008-11       Impact factor: 3.325

5.  Sex-specific differences in chromosome-dependent regulation of vascular reactivity in female consomic rat strains from a SSxBN cross.

Authors:  Mary Pat Kunert; Melinda R Dwinell; Ines Drenjancevic Peric; Julian H Lombard
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-05-28       Impact factor: 3.619

6.  The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.

Authors:  Darren A Cusanovich; Christine Billstrand; Xiang Zhou; Claudia Chavarria; Sherryl De Leon; Katelyn Michelini; Athma A Pai; Carole Ober; Yoav Gilad
Journal:  Hum Mol Genet       Date:  2012-01-27       Impact factor: 6.150

7.  Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip.

Authors:  Ankita Parihar; G Craig Wood; Xin Chu; Qunjan Jin; George Argyropoulos; Christopher D Still; Alan R Shuldiner; Braxton D Mitchell; Glenn S Gerhard
Journal:  Front Genet       Date:  2014-08-05       Impact factor: 4.599

8.  Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males.

Authors:  Yao-Zhong Liu; Yu-Fang Pei; Jian-Feng Liu; Fang Yang; Yan Guo; Lei Zhang; Xiao-Gang Liu; Han Yan; Liang Wang; Yin-Ping Zhang; Shawn Levy; Robert R Recker; Hong-Wen Deng
Journal:  PLoS One       Date:  2009-08-28       Impact factor: 3.240

9.  A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity.

Authors:  Chenguang Wang; Yun Cheng; Tian Liu; Qin Li; Roger B Fillingim; Margaret R Wallace; Roland Staud; Lee Kaplan; Rongling Wu
Journal:  Mol Pain       Date:  2008-04-16       Impact factor: 3.395

10.  Systematic review reveals multiple sexually antagonistic polymorphisms affecting human disease and complex traits.

Authors:  Jon Alexander Harper; Tim Janicke; Edward H Morrow
Journal:  Evolution       Date:  2021-11-12       Impact factor: 4.171
  10 in total

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