Literature DB >> 10641559

Genome-wide screen for atopy susceptibility alleles in the Hutterites.

C Ober1, A Tsalenko, S Willadsen, D Newman, R Daniel, X Wu, J Andal, D Hoki, D Schneider, K True, C Schou, R Parry, N Cox.   

Abstract

A genome-wide screen for loci influencing positive skin prick tests (SPT) to airborne allergens was conducted in the Hutterites, a founder population of European ancestry. Positive SPT to 14 standardized allergens was measured in 370 subjects in our primary sample and 324 subjects in a replication sample. Evidence for linkage to positive SPT was assessed using the transmission disequilibrium test (TDT) with 337 autosomal markers (average spacing 9.13 cM, SD = 7.8 cM). Three loci showed the strongest overall evidence of linkage to atopy, with at least one allele-specific and a locus-specific p< 1 x 10(-4). This study provides evidence for at least three atopy-susceptibility loci in the Hutterites on chromosomes 1, 6 and 16.

Mesh：

Year:  1999        PMID： 10641559

Source DB:  PubMed          Journal:  Clin Exp Allergy        ISSN： 0954-7894            Impact factor:   5.018


  15 in total

1.  Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.

Authors:  C Ober; S A Leavitt; A Tsalenko; T D Howard; D M Hoki; R Daniel; D L Newman; X Wu; R Parry; L A Lester; J Solway; M Blumenthal; R A King; J Xu; D A Meyers; E R Bleecker; N J Cox
Journal:  Am J Hum Genet       Date:  2000-02       Impact factor: 11.025

2.  A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.

Authors:  C Ober; A Tsalenko; R Parry; N J Cox
Journal:  Am J Hum Genet       Date:  2000-10-05       Impact factor: 11.025

3.  Genomewide scans of complex human diseases: true linkage is hard to find.

Authors:  J Altmüller; L J Palmer; G Fischer; H Scherb; M Wjst
Journal:  Am J Hum Genet       Date:  2001-09-14       Impact factor: 11.025

Review 4.  Gene-environment interactions in asthma: with apologies to William of Ockham.

Authors:  Fernando D Martinez
Journal:  Proc Am Thorac Soc       Date:  2007-01

5.  Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness.

Authors:  Ke Hao; Tianhua Niu; Xin Xu; Zhian Fang; Xiping Xu
Journal:  Hum Genet       Date:  2005-02-16       Impact factor: 4.132

Review 6.  Asthma in Hispanics.

Authors:  Gary M Hunninghake; Scott T Weiss; Juan C Celedón
Journal:  Am J Respir Crit Care Med       Date:  2005-10-06       Impact factor: 21.405

7.  The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population.

Authors:  M-A Kedda; F Lose; D Duffy; E Bell; P J Thompson; J Upham
Journal:  Thorax       Date:  2005-03       Impact factor: 9.139

8.  A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.

Authors:  Jayant M Pinto; M Geoffrey Hayes; Daniel Schneider; Robert M Naclerio; Carole Ober
Journal:  Laryngoscope       Date:  2008-11       Impact factor: 3.325

9.  Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma.

Authors:  Tomomitsu Hirota; Kazuhiko Obara; Akira Matsuda; Mitsuteru Akahoshi; Kazuko Nakashima; Koichi Hasegawa; Naomi Takahashi; Makiko Shimizu; Hiroshi Sekiguchi; Miki Kokubo; Satoru Doi; Hiroshi Fujiwara; Akihiko Miyatake; Kimie Fujita; Tadao Enomoto; Fumio Kishi; Yoichi Suzuki; Hirohisa Saito; Yusuke Nakamura; Taro Shirakawa; Mayumi Tamari
Journal:  J Hum Genet       Date:  2004-06-04       Impact factor: 3.172

10.  Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.

Authors:  Carole Ober; Lin Pan; Natasha Phillips; Rodney Parry; Lianne M Kurina
Journal:  Curr Allergy Asthma Rep       Date:  2006-05       Impact factor: 4.919
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